Meta-analysis of the functional neuroanatomy of single-word reading: Method and validation
Meta-analysis of the functional neuroanatomy of single-word reading: Method and validation
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DOI：
10.1006/nimg.2002.1131
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发表时间：
2002-07-01
期刊：
影响因子：
5.7
通讯作者：
Zeffiro, TA
中科院分区：
文献类型：
--
作者：
Turkeltaub, PE;Eden, GF;Zeffiro, TA
实验设计中的个体间差异和细微差异会导致认知过程研究（如阅读）结果的差异。为了准确地识别与认知和感觉运动处理相关的神经过程，元分析方法能够识别研究中一致激活的区域是有用的。本文描述了一种新的方法，结合多项研究的神经影像学结果，旨在最大限度地量化研究间的一致性，同时最大限度地减少荟萃分析的主观方面。在该方法中，对从11个大声阅读单个单词的PET研究中获得的每个激活焦点进行定位概率分布建模，并将这些分布合并以产生大脑的激活似然估计图。通过随机产生的病灶组的排列分析评估显著性。在双侧运动皮质和上级颞叶皮质、SMA前区、左梭状回和小脑中发现了显著一致的区域。这些荟萃分析的结果进行了验证，与新的功能磁共振成像数据大声阅读在正常成人科目。观察到两个统计图之间的良好对应关系，fMRI最大值接近所有荟萃分析峰值，两种技术确定的峰值处的统计值强烈相关。PET荟萃分析和fMRI结果之间的密切对应关系也证明了使用fMRI研究涉及明显言语反应的语言任务的有效性。这种自动化荟萃分析技术的优点包括量化所有大脑位置的一致性水平，并提供使用一致性的统计学显著性阈值。(C)2002 Elsevier Science（美国）。
Intersubject variability and subtle differences in experimental design can lead to variable results in studies of cognitive processes such as reading. To accurately identify the neural processes associated with cognition and sensorimotor processing, meta-analytic methods capable of identifying areas of consistent activation among studies are useful. This paper describes a novel approach for combining published neuroimaging results from multiple studies, designed to maximize the quantification of interstudy concordance while minimizing the subjective aspects of meta-analysis. In this method, a localization probability distribution was modeled for each activation focus obtained from 11 PET studies of reading single words aloud, and the union of these distributions was taken to yield an activation likelihood estimate map for the brain. Significance was assessed via permutation analysis of randomly generated sets of foci. Regions of significant concordance were identified in bilateral motor and superior temporal cortices, pre-SMA, left fusiform gyrus, and the cerebellum. These meta-analytic results were validated by comparison with new fMRI data on aloud word reading in normal adult subjects. Excellent correspondence between the two statistical maps was observed, with fMRI maxima lying close to all meta-analysis peaks and statistical values at the peaks identified by the two techniques correlating strongly. This close correspondence between PET meta-analysis and fMRI results also demonstrates the validity of using fMRI for the study of language tasks involving overt speech responses. Advantages of this automated meta-analysis technique include quantification of the level of concordance at all brain locations and the provision for use of a threshold for statistical significance of concordance. (C) 2002 Elsevier Science (USA).