The interaction between beta-3 adrenergic receptor polymorphism and obesity to periodontal disease in community-dwelling elderly Japanese
The interaction between beta-3 adrenergic receptor polymorphism and obesity to periodontal disease in community-dwelling elderly Japanese
复制标题
日本社区老年人β3肾上腺素受体多态性与肥胖与牙周病的相互作用
DOI：
10.1111/jcpe.12235
复制
发表时间：
2014
影响因子：
6.7
通讯作者：
Nakamura K
中科院分区：
文献类型：
--
作者：
Yoshihara A;Sugita N;Iwasaki M;Miyazaki H;Nakamura K
ObjectivesThe purpose of this study was to eliminate whether the association beta-3 adrenergic receptor polymorphism and牙周病are modified by body weight.Material and MethodsWe enrolled 332 postmenopausal women and determined their HbA1C levels（%）and beta-3 adrenergic receptor（rs4994）genotype.测量包括临床附着水平（CAL）在内的牙周参数。在选择每个体重指数（BMI）水平的受试者后，通过多重Poisson回归分析计算患病率比（PRR），以评估牙周病与β 3肾上腺素能受体多态性之间的关系。CAL≥6 mm的研究中心数量作为因变量，β-3肾上腺素能受体基因型[分类为Arg非携带者（参考）或Arg携带者]、年龄（y）和HbA 1C（%）作为自变量。我们将探测位点的数量（n）转换为一个偏移variable.ResultsThe PRR的β-3肾上腺素能受体基因型的CAL≥6 mm的网站的数量在BMI≥25.0的受试者中显示出正相关，并与BMI显着增加。BMI≥30的受试者的PRR为3.10（p<0.0001）。结论本研究表明肥胖个体的牙周病与β-3肾上腺素能受体基因型呈正相关。
ObjectivesThe purpose of this study was to elucidate whether the association between beta‐3 adrenergic receptor polymorphism and periodontal disease is modified by body weight.Material and MethodsWe enrolled 332 postmenopausal women and determined their HbA1C levels (%) and beta‐3 adrenergic receptor (rs4994) genotypes. Periodontal parameters including clinical attachment level (CAL) were measured. After selecting subjects for each body mass index (BMI) level, the prevalence rate ratio (PRR) by multiple Poisson regression analysis was calculated to evaluate the relationship between periodontal disease and beta‐3 adrenergic receptor polymorphism. The number of sites with CAL≥6 mm was used as a dependent variable, and beta‐3 adrenergic receptor genotype [categorized as Arg non‐carriers (reference) or Arg carriers], age (y) and HbA1C (%) were adopted as independent variables. We converted the number of probing sites (n) to an offset variable.ResultsThe PRR of the beta‐3 adrenergic receptor genotype for the number of sites of CAL≥6 mm showed a positive association in subjects with BMI≥25.0 and increased markedly with BMI. The PRR in subjects with BMI≥30 was 3.10 (p<0.0001).ConclusionThis study indicates a positive association between periodontal disease and the beta‐3 adrenergic receptor genotype in obese individuals.