Anti-inflammatory effects of theophylline: modulation of immune functions during murine leukemia virus infection.
Anti-inflammatory effects of theophylline: modulation of immune functions during murine leukemia virus infection.
复制标题
茶碱的抗炎作用：小鼠白血病病毒感染期间免疫功能的调节。
DOI：
10.1081/iph-100107332
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发表时间：
2001
影响因子：
3.3
通讯作者：
Watson,RR
中科院分区：
文献类型：
--
作者：
Liang,B;Jiang,S;Zhang,Z;Inserra,P;Lee,J;Solkoff,D;Watson,RR
Lp-BM5小鼠白血病病毒通过细胞因子dsys调节诱导免疫功能紊乱，导致B细胞白血病和小鼠艾滋病。茶碱可诱导人类白血病细胞的凋亡。因此，我们研究了茶碱对白血病小鼠免疫功能障碍的影响。C57BL/6小鼠在感染逆转录病毒后2周开始饮用含0.3%茶碱的饮用水，连续4个月。茶碱在很大程度上阻止了逆转录病毒引起的脾肿大、淋巴病变、B和T细胞增殖减少以及Th1细胞因子(IL-2)的分泌受到抑制。它还抑制Th2细胞因子(IL-4、TNF-α和IL-10)的产生，而逆转录病毒感染则会刺激Th2细胞因子的产生。这些数据表明，由小鼠逆转录病毒感染引起的免疫功能障碍在很大程度上可以通过茶碱治疗来预防。
LP-BM5 murine leukemia virus induces immune dysfunction leading to B cell leukemia and murine AIDS with cytokine dsyregulation. Theophylline induces apoptosis of leukemia cells in humans. Therefore the effects of theophylline on immune dysfunction in a murine model of leukemia were investigated. C57BL/6 mice consumed drinking water containing 0.3% theophylline beginning 2 weeks after murine retrovirus infection for 4 months. Theophylline largely prevented the retrovirus induced splenomagaly, lymphodenopathy, reduction in B and T cell proliferation, and suppression of Th1 cytokines (IL-2) secretion. It also suppressed Th2 cytokine (IL-4, TNF-alpha, and IL-10) production, which was otherwise stimulated by retrovirus infection. These data suggest that immune dysfunction, induced by murine retrovirus infection, was largely prevented by theophylline treatment.