Surrogate markers of intestinal inflammation are predictive of relapse in patients with inflammatory bowel disease
Surrogate markers of intestinal inflammation are predictive of relapse in patients with inflammatory bowel disease
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DOI：
10.1053/gast.2000.8523
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发表时间：
2000-07-01
期刊：
影响因子：
29.4
通讯作者：
Bjarnason, I
中科院分区：
文献类型：
--
作者：
Tibble, JA;Sigthorsson, G;Bjarnason, I
背景和目标：炎症性肠病复发的预测对于治疗策略具有重要意义。我们评估了肠通透性和炎症的测量是否可以预测炎症性肠病（IBD）的复发。43例克罗恩病（CD）和37例溃疡性结肠炎（UC）临床缓解期患者提供粪便样本进行钙卫蛋白测定（嗜中性粒细胞特异性标志物），CD患者还进行了小肠通透性试验。使用临床疾病活动指数定义复发。结果：25例（58%）CD患者和19例（51%）UC患者在12个月期间复发。复发组中的中位钙卫蛋白水平（CD为122 mg/L，UC为123 mg/L;正常
Background&Aims: Prediction of relapse of inflammatory bowel disease has important implications for therapeutic stategies, We assessed whether measurement of intestinal permeability and inflammation could predict relapse of inflammatory bowel disease (IBD), Methods: Forty-three patients with Crohn's disease (CD) and 37 with ulcerative colitis (UC) in clinical remission provided a stool sample to be assayed for calprotectin (a neutrophil-specific marker), and patients with CD additionally underwent a small intestinal permeability test. Relapse was defined using clinical disease activity indices. Results: Twenty-five (58%) patients with CD and 19 (51%) with UC had a relapse over the 12-month period. Median calprotectin levels in the relapse groups (122 mg/L for CD, 123 mg/L for UC; normal