Growth mechanisms of endometriotic cells in implanted places: a review
Growth mechanisms of endometriotic cells in implanted places: a review
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子宫内膜异位细胞在植入部位的生长机制：综述
DOI：
10.3109/09513590.2011.650662
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发表时间：
2012-07-01
影响因子：
2
通讯作者：
Wu, Rui-Jin
中科院分区：
文献类型：
--
作者：
Jiang, Qiao-Ying;Wu, Rui-Jin
子宫内膜异位症是一种常见的妇科疾病，其定义为子宫内膜腺体和间质的宫外生长。已经提出了各种理论来解释这种疾病的发病机制，包括逆行移植理论，体腔上皮化生，造血和淋巴扩散，以及苗勒管残留。然而，子宫内膜异位症的发病机制仍不清楚。本文就子宫内膜异位症患者种植部位异位细胞的生长机制，包括异位细胞的粘附、侵袭、血管生成、增殖、凋亡、免疫分子的变化以及异位细胞自身的变化等方面进行综述，为进一步研究子宫内膜异位症的发病机制提供线索。
Endometriosis is a common gynecological disease defined by extrauterine growth of endometrial glands and stroma. A variety of theories have been proposed to account for the pathogenesis of this disease, including retrograde transplantation theory, metaplasia of coelomic epithelium, hematogenic and lymphogenic spread, and remnants of the Mŭllerian duct. However, the etiopathology of endometriosis is still obscure. In this article, we aim to summarize recent researches concerning the growth mechanisms of endometriotic cells in implanted sites systematically, including the adhesion, invasion, angiogenesis, proliferation, apoptosis of endometriotic cells, variations of the immune molecules and endometriotic cells themselves, which may provide clues for future researches in the pathogenesis of endometriosis.