Proceedings of the third international molecular pathological epidemiology (MPE) meeting.
Proceedings of the third international molecular pathological epidemiology (MPE) meeting.
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DOI：
10.1007/s10552-016-0845-z
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发表时间：
2017-02
期刊：
影响因子：
--
通讯作者：
Ogino S
中科院分区：
文献类型：
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作者：
Campbell PT;Rebbeck TR;Nishihara R;Beck AH;Begg CB;Bogdanov AA;Cao Y;Coleman HG;Freeman GJ;Heng YJ;Huttenhower C;Irizarry RA;Kip NS;Michor F;Nevo D;Peters U;Phipps AI;Poole EM;Qian ZR;Quackenbush J;Robins H;Rogan PK;Slattery ML;Smith-Warner SA;Song M;VanderWeele TJ;Xia D;Zabor EC;Zhang X;Wang M;Ogino S
分子病理流行病学（Molecular Pathological Epidemiology，MPE）是一门跨学科的新兴学科，它整合了流行病学、病理学、生物统计学、生物信息学和计算生物学的理论、方法和资源。MPE研究的基本目标是更好地了解复杂和异质性人类疾病的病因和进展，目的是为人口健康和临床医学的预防和治疗工作提供信息。虽然MPE研究通常用于研究乳腺癌、肺癌和结直肠癌，但其方法可用于研究大多数疾病。MPE研究的最新成功包括：1）开发新的统计方法来解决病因异质性; 2）加强因果推理; 3）识别以前未知的疾病亚型关联; 4）更好地理解生活方式/行为因素对根据疾病亚型改变预后的作用。MPE面临的主要挑战包括相对缺乏跨学科专家，教育计划和论坛来讨论与该领域发展相关的问题。为了应对这些挑战，强调该领域最近的成功，并确定新的机会，在马萨诸塞州波士顿的Dana-Farber癌症研究所举行了一系列MPE会议。在此，我们分享2016年5月举行的第三届国际MPE会议的会议记录，来自17个国家的150名科学家参加了会议。专题包括MPE与免疫学和健康差异研究的整合。这一系列会议将继续推动不同科学领域的进一步跨学科融合。
Molecular pathological epidemiology (MPE) is a transdisciplinary and relatively new scientific discipline that integrates theory, methods and resources from epidemiology, pathology, biostatistics, bioinformatics and computational biology. The underlying objective of MPE research is to better understand the etiology and progression of complex and heterogeneous human diseases with the goal of informing prevention and treatment efforts in population health and clinical medicine. Although MPE research has been commonly applied to investigating breast, lung, and colorectal cancers, its methodology can be used to study most diseases. Recent successes in MPE studies include: 1) the development of new statistical methods to address etiologic heterogeneity; 2) the enhancement of causal inference; 3) the identification of previously unknown exposure-subtype disease associations; and 4) better understanding of the role of lifestyle/behavioral factors on modifying prognosis according to disease subtype. Central challenges to MPE include the relative lack of transdisciplinary experts, educational programs, and forums to discuss issues related to the advancement of the field. To address these challenges, highlight recent successes in the field, and identify new opportunities, a series of MPE meetings have been held at the Dana-Farber Cancer Institute in Boston, MA. Herein, we share the proceedings of the Third International MPE Meeting, held in May 2016 and attended by 150 scientists from 17 countries. Special topics included integration of MPE with immunology and health disparity research. This meeting series will continue to provide an impetus to foster further transdisciplinary integration of divergent scientific fields.