Down-regulation of succinate dehydrogenase subunit B and up-regulation of pyruvate dehydrogenase kinase 1 predicts poor prognosis in recurrent nasopharyngeal carcinoma
Down-regulation of succinate dehydrogenase subunit B and up-regulation of pyruvate dehydrogenase kinase 1 predicts poor prognosis in recurrent nasopharyngeal carcinoma
复制标题
DOI：
10.1007/s13277-015-4107-6
复制
发表时间：
2016-04-01
期刊：
影响因子：
--
通讯作者：
Lin, Sen
中科院分区：
文献类型：
--
作者：
Dai, ZhiJian;Pan, Shenhua;Lin, Sen
琥珀酸脱氢酶亚基B （SDHB）和丙酮酸脱氢酶激酶1 （PDK1）在多种癌症的生长和存活调控中起关键作用。本研究旨在探讨SDHB和PDK1在复发性鼻咽癌（rNPC）组织中的表达，并分析SDHB和PDK1表达与rNPC的临床意义及潜在预后的关系。免疫组化检测原发性NPC （pNPC）和rNPC患者组织中SDHB和PDK1的表达。我们的结果显示，SDHB在rNPC中的表达明显低于pNPC，而PDK1的表达高于pNPC。SDHB和PDK1的表达水平与rNPC的T分期、N分期、临床分期及转移有关。生存分析显示，SDHB低表达患者的总生存时间明显短于SDHB高表达患者。PDK1高表达患者的生存时间短于PDK1低表达患者。多因素分析显示，SDHB和PDK1的表达是rNPC患者生存的独立预测因子。我们的研究结果表明，SDHB的下调和PDK1的上调可能是预测rNPC患者晚期肿瘤进展和不良预后的新生物标志物。
Succinate dehydrogenase subunit B (SDHB) and pyruvate dehydrogenase kinase 1 (PDK1) play key roles in the regulation of growth and survival of various cancers. This study aimed to investigate expression of SDHB and PDK1 in recurrent nasopharyngeal carcinoma (rNPC) tissues and analyzed the association of SDHB and PDK1 expression with the clinical significance and potential prognostic implication of rNPC. Immunohistochemistry was performed to determine the expression of SDHB and PDK1 in tissues in primary NPC (pNPC) and rNPC patients. Our results revealed that expression of SDHB in rNPC was significantly lower than that in pNPC, while the expression of PDK1 was higher compared to pNPC. The expression levels of SDHB and PDK1 were associated with T stage, N stage, clinical stage, and metastasis of rNPC. Survival analysis showed that patients with low SDHB expression had a significantly shorter overall survival time than those with high SDHB expression. Patients with high PDK1 expression had a shorter survival time than patients with low PDK1 expression. Multivariate analysis showed that the expression of SDHB and PDK1 was an independent predictor for the survival of patients with rNPC. Our results demonstrated that down-regulation of SDHB and up-regulation of PDK1 may be novel biomarkers for predicting advanced tumor progression and unfavorable prognosis in rNPC patients.