Characterizing declines in pediatric antidepressant use after new risk disclosures.
Characterizing declines in pediatric antidepressant use after new risk disclosures.
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DOI：
10.1177/1077558710374197
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发表时间：
2011-02
期刊：
影响因子：
--
通讯作者：
Barry CL
中科院分区：
文献类型：
--
作者：
Busch SH;Frank RG;Martin A;Barry CL
2004 年发布新的安全信息，将抗抑郁药与自杀风险联系起来后，儿童抗抑郁药的使用急剧下降。我们研究了具有某些临床或家庭特征的个体中儿科抗抑郁药使用的下降是否更为急剧。我们发现抗抑郁药物使用量的下降与新的（与正在进行的）治疗事件有关。此外，尽管在风险披露之前，受过大学教育的父母的孩子抗抑郁药物的使用率较高，但在风险披露之后，这些孩子比受教育程度较低的父母的孩子更有可能放弃抗抑郁药物。我们发现，在风险警告之后，无论有没有精神障碍的儿童，抗抑郁药物的使用都出现了下降，尽管后者的下降速度更快。我们的研究结果强调需要额外的数据来评估风险披露对治疗模式和健康结果的影响。
Steep declines in pediatric antidepressant use were documented following the 2004 release of new safety information associating antidepressants with a risk of suicidality. We examine whether declines in pediatric antidepressant use were steeper among individuals with certain clinical or family characteristics. We find that declines in antidepressant use were associated with new (as compared to ongoing) treatment episodes. Also, although rates of antidepressant use were higher among children of college educated parents prior to risk disclosures, these children were more likely to forgo antidepressant medication than children of less educated parents after risk disclosures. We find that both children with and without psychiatric impairment experienced declines in antidepressant medication use following the risk warnings, although the decline occurred more quickly in the latter group. Our findings highlight the need for additional data to assess the effects of risk disclosures on treatment patterns and health outcomes.
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影响因子：
9.7
作者：
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通讯作者：
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影响因子：
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作者：
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DOI：
10.1097/chi.0b013e3181b5dbe4
发表时间：
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影响因子：
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作者：
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