Nutrient signals driving cell growth
Nutrient signals driving cell growth
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DOI：
10.1016/j.ceb.2008.09.009
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发表时间：
2008-12-01
影响因子：
7.5
通讯作者：
Peter, Matthias
中科院分区：
文献类型：
--
作者：
Dechant, Reinhard;Peter, Matthias
调节细胞生长对营养物质的反应对所有生物体的生存至关重要。在酵母中，细胞生长和分裂需要两个信号通路，TORC 1和PKA。这些通路的激活关键取决于细胞内代谢信号，但其机制仍然难以捉摸。最近的研究已经确定了TORC 1的潜在激活剂，并强调了内膜系统的关键作用。此外，钙被认为是响应于氨基酸水平的TORC 1激活的重要第二信使。相反，遗传分析表明PKA的激活依赖于细胞内葡萄糖代谢产物。再加上新的定量方法，这些发现为我们理解酵母和人类营养传感的分子机制提供了重要的基础。
Regulation of cell growth in response to nutrients is crucial for the survival of all organisms. In yeast, cell growth and division require two signaling pathways, TORC1 and PKA. Activation of these pathways crucially depends on intracellular metabolic signals, but the mechanisms remain elusive. Recent studies have identified potential activators of TORC1 and have highlighted a crucial role for the endomembrane system. Moreover, calcium was recognized as an important second messenger for TORC1 activation in response to amino acid levels. On the contrary, genetic analysis indicates that PKA activation depends on an intracellular glucose metabolite. Together with novel quantitative approaches, these findings provide important groundwork in our understanding of the molecular mechanisms for nutrient sensing in yeast and humans.