Minor Allele C of Chromosome 1p32 Single Nucleotide Polymorphism rs11206510 Confers Risk of Ischemic Stroke in the Chinese Han Population
Minor Allele C of Chromosome 1p32 Single Nucleotide Polymorphism rs11206510 Confers Risk of Ischemic Stroke in the Chinese Han Population
复制标题
染色体1p32单核苷酸多态性rs11206510的小等位基因C赋予中国汉族人群缺血性中风的风险
DOI：
10.1161/strokeaha.110.583096
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发表时间：
2010-08-01
期刊：
影响因子：
8.3
通讯作者：
Wang, Qing K.
中科院分区：
文献类型：
--
作者：
Xu, Chengqi;Wang, Fan;Wang, Qing K.
背景和目的全基因组关联研究发现，染色体 1p32 上单核苷酸多态性 rs11206510 的常见等位基因 T 与白人低密度脂蛋白胆固醇水平 (LDL-C) 升高以及冠状动脉疾病 (CAD) 风险相关。本研究的目的是确定 rs11206510 是否与不同种族人群（即中国队列）中的 LDL-C 和 CAD 相关，并调查 rs11206510 是否与缺血性中风相关。 方法 - 在 1415 名中国汉族受试者中分析 rs11206510 与 LDL-C 的关联。 CAD 研究利用了包含 1543 名 CAD 患者和 1240 名对照者的 GeneID 队列。对于中风研究，使用了 2 个独立队列，其中包括 GeneID North 队列（包含 1205 例病例和 1205 名对照）和 GeneID Central 队列（包含 692 例病例和 882 名对照）。 结果 - 与白人群体不同，rs11206510 的次要等位基因 C 与中国汉族人群中 LDL-C 水平升高相关（调整后的 P=0.002）并赋予早发风险CAD（380 例病例对比 1240 例对照；调整后的 P=0.002，比值比为 1.89），但总体 CAD 则不然（调整后的 P=0.82）。等位基因与缺血性中风的相关性在 2 个独立队列中高度显着，在 GeneID North 队列中调整后的 P=1.13x10(-5)（比值比，1.71），在 GeneID Central 队列中调整后的 P=9.32x10(-5)（比值比，1.70）。基因型关联对于早发性 CAD 和缺血性中风也很重要。结论 - 我们的结果表明单核苷酸多态性 rs11206510 与中国汉族人群中的 LDL-C 水平和早发性 CAD 相关。据我们所知，这项研究还首次证明 rs11206510 具有显着的缺血性中风风险。 （中风。2010；41：1587-1592。）
Background and Purpose-Genome-wide association studies found that the common allele T of single nucleotide polymorphism rs11206510 on chromosome 1p32 was associated with increased low-density lipoprotein-cholesterol levels (LDL-C) and with risk of coronary artery disease (CAD) in white populations. The goals of this study are to determine whether rs11206510 is associated with LDL-C and CAD in a different ethnic population, namely a Chinese cohort, and to investigate whether rs11206510 is associated with ischemic stroke.Methods-The association of rs11206510 with LDL-C was analyzed in 1415 Chinese Han subjects. The CAD study utilized a GeneID cohort with 1543 CAD patients and 1240 controls. For stroke studies, 2 independent cohorts were used and included the GeneID North cohort, with 1205 cases and 1205 controls, and the GeneID Central cohort, with 692 cases and 882 controls.Results-Different from white populations, the minor allele C of rs11206510 was associated with increased LDL-C levels in the Chinese Han population (adjusted P=0.002) and conferred risk of early-onset CAD (380 cases vs 1240 controls; adjusted P=0.002, odds ratio, 1.89), but not with overall CAD (adjusted P=0.82). The allelic association with ischemic stroke was highly significant in 2 independent cohorts, with adjusted P=1.13x10(-5) (odds ratio, 1.71) in the GeneID North cohort and adjusted P=9.32x10(-5) (odds ratio, 1.70) in the GeneID Central cohort. Genotypic association was also significant for both early-onset CAD and ischemic stroke.Conclusions-Our results indicate that single nucleotide polymorphism rs11206510 is associated with LDL-C levels and early-onset CAD in the Chinese Han population. For the first time to our knowledge, this study also demonstrates that rs11206510 confers a significant risk of ischemic stroke. (Stroke. 2010; 41:1587-1592.)