Semiconductor Nanowire‐Based Cellular and Subcellular Interfaces
Semiconductor Nanowire‐Based Cellular and Subcellular Interfaces
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DOI：
10.1002/adfm.202107997
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发表时间：
2021-10
影响因子：
19
通讯作者：
Jiuyun Shi;Changxu Sun;Elaine Liang;B. Tian
中科院分区：
文献类型：
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作者：
Jiuyun Shi;Changxu Sun;Elaine Liang;B. Tian
生物系统的高度复杂结构使得在细胞水平上精确探测生物行为特别困难。作为一种能够探索各种生物界面的先进工具，高纵横比纳米线以其独特的机械、光学和电学特性脱颖而出。具体地说，半导体纳米线在其可调谐性和合成和制造的可行性方面显示出很大的希望。到目前为止，半导体纳米线已经在破译生物通信和通过基于纳米线的生物界面翻译这种细胞语言方面显示出有利的结果。从这个角度来看，合成和制造方法的不同种类的纳米线和纳米线为基础的结构进行了调查。接下来，重点介绍了几种细胞级纳米线在生物物理动力学探测、生理或生化传感以及生物活性调节方面的应用。然后综述了功能化纳米线在药物输送和生物能源生产方面的研究进展。最后，总结了纳米线目前的局限性，并展望了下一代基于纳米线的生物界面器件。
The highly intricate structures of biological systems make the precise probing of biological behaviors at the cellular‐level particularly difficult. As an advanced toolset capable of exploring diverse biointerfaces, high‐aspect‐ratio nanowires stand out with their unique mechanical, optical, and electrical properties. Specifically, semiconductor nanowires show much promise in their tunability and feasibility for synthesis and fabrication. Thus far, semiconductor nanowires have shown favorable results in deciphering biological communications and translating this cellular language through the nanowire‐based biointerfaces. In this perspective, the synthesis and fabrication methods for different kinds of nanowires and nanowire‐based structures are first surveyed. Next, several cellular‐level nanowire‐enabled applications in biophysical dynamics probing, physiological or biochemical sensing, and biological activity modulation are highlighted. Then, the progress of functionalized nanowires in drug delivery and bioenergy production is reviewed. Finally, the current limitations of nanowires and an outlook into the next generation of nanowire‐based devices at the biointerfaces are concluded.