Long-term use of proton pump inhibitors does not affect the frequency, growth, or histologic characteristics of colon adenomas.
Long-term use of proton pump inhibitors does not affect the frequency, growth, or histologic characteristics of colon adenomas.
复制标题
长期使用质子泵抑制剂不会影响结肠腺瘤的发生频率、生长或组织学特征。
DOI：
10.1111/j.1365-2036.2007.03450.x
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发表时间：
2007
影响因子：
7.6
通讯作者：
Triadafilopoulos,G
中科院分区：
文献类型：
--
作者：
Singh,M;Dhindsa,G;Friedland,S;Triadafilopoulos,G
背景长期质子泵抑制剂 (PPI) 相关的高胃泌素血症对结肠息肉的营养影响尚不清楚。目的研究与未接受抑酸治疗的患者（对照）相比，接受长期 PPI 治疗的患者（病例）结肠息肉的发生频率、生长和组织学。方法回顾了 2868 名连续接受两次或两次以上结肠镜检查（相隔 3 个月或以上）的患者的医疗记录。然后将两次结肠镜检查之间使用 PPI 的病例 (116) 与对照 (194) 进行比较。结果两组之间的人口统计学和结肠癌危险因素具有可比性。基线时，病例和对照组腺瘤性息肉的平均频率和大小相似（P> 0.05），随访时分别为 0.89 和 1.18（P> 0.05；95% CI 为 -0.08 至 0.66）以及 4.09 mm 和 4.00 mm（P> 0.05；95% CI -2.29 至 2.11）。没有显着变化。然而，对照组在基线和随访结肠镜检查时增生性息肉的平均频率和大小较高（P < 0.05）。结论长期使用 PPI 不会影响腺瘤性息肉的频率、生长或组织学，但与基线和间隔期增生性息肉发展的减少有关。
BackgroundThe clinical significance of the trophic effects of long‐term proton pump inhibitors (PPI)‐related hypergastrinemia on colon polyps remains unknown.AimTo study the frequency, growth, and histology of colon polyps in patients on chronic PPI therapy (cases), compared to those not receiving acid suppression (controls).MethodsMedical records of 2868 consecutive patients who underwent two or more colonoscopies, performed 3 or more months apart were reviewed. Cases (116) that used PPIs between the two colonoscopies were then compared to controls (194).ResultsDemographics and risk factors for colon cancer were comparable between the two groups. At baseline the mean frequency and size of adenomatous polyps were similar in cases and controls (P> 0.05) and at follow‐up, these were 0.89 and 1.18 (P> 0.05; 95% CI of −0.08 to 0.66) and 4.09 mm and 4.00 mm (P> 0.05; 95% CI −2.29 to 2.11), respectively with no significant change. However, control group had a higher mean frequency and size of hyperplastic polyps at baseline as well as at follow‐up colonoscopy (P< 0.05).ConclusionsThe long‐term use of PPI does not influence the frequency, growth, or histology of adenomatous polyps, but is associated with a reduction in both baseline and interval development of hyperplastic polyps.