ARGENTINE HEMORRHAGIC-FEVER - ALTERATIONS OF COMPLEMENT-SYSTEM AND ANTI-JUNIN-VIRUS HUMORAL RESPONSE
ARGENTINE HEMORRHAGIC-FEVER - ALTERATIONS OF COMPLEMENT-SYSTEM AND ANTI-JUNIN-VIRUS HUMORAL RESPONSE
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DOI：
10.1056/nejm197808032990502
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发表时间：
1978-01-01
影响因子：
158.5
通讯作者：
ARANA, RM
中科院分区：
文献类型：
--
作者：
DEBRACCO, MME;RIMOLDI, MT;ARANA, RM
我们研究了补体在阿根廷出血热发病机制中的作用和免疫学机制，阿根廷出血热是由沙粒病毒组的成员之一朱宁病毒引起的一种疾病，在重度或中度疾病患者中，总血清补体活性降低至对照值的68%（P<0.001）。C2、C3和C5值在疾病早期急性期也很低（12%至60%）。然而，血清C4含量增加到160%的控制值在相同的患者。在检测到抗朱宁病毒抗体时，总补体活性随临床和实验室恢复而恢复正常。C1 q反应物质被发现在19例中的4例，并没有关系的疾病的演变可以建立。这些结果表明，免疫复合物在阿根廷出血热的发病机制中并不重要，但补体系统的激活具有一定的作用。（《新英格兰医学杂志》299：216-221，1978）
We investigated immunologic mechanisms and the role of complement in the pathogenesis of Argentine hemorrhagic fever, a disease caused by the Junin virus, a member of the arenavirus group.Total serum complement activity was reduced to 68 per cent of control values in patients with severe or moderate disease (P<0.001). C2, C3 and C5 values were also low (12 to 60 per cent) during the early acute period of the disease. However, serum C4 content was increased to 160 per cent of the control values in the same patients. Total complement activity returned to normal with clinical and laboratory recovery, at the time of detection of antibodies against Junin virus. C1q reactive material was found in four of 19 cases and no relation to the evolution of the disease could be established. These results suggest that immune complexes are not important in the pathogenesis of Argentine hemorrhagic fever, but that activation of the complement system has a role. (N Engl J Med 299:216–221, 1978)