Immortalization and transformation of human cells by human papillomavirus.
Immortalization and transformation of human cells by human papillomavirus.
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人乳头瘤病毒对人类细胞的永生化和转化。
DOI：
10.1007/978-3-642-78487-3_6
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发表时间：
1994
影响因子：
--
通讯作者：
McDougall,JK
中科院分区：
文献类型：
--
作者：
McDougall,JK
人类乳头状瘤病毒（HPV）与肛门生殖器癌的关联现在得到了如此压倒性的证据的支持，即使是对病毒/癌症假说最持怀疑态度的批评者也必须注意。然而，当客观地检查数据时，很明显，正如已经研究的许多甚至所有癌症病因一样，不止一个因素参与了恶性肿瘤的进展。HPV可能是这种疾病的主要参与者，可能是启动和维持该过程所必需的，但对于浸润性癌的最终表现可能是不够的。HPV基因表达对培养的原代人细胞的影响的体外研究为评价病毒基因产物与细胞基因相互作用引起的表型变化提供了基础。
The association of human papillomaviruses (HPVs) with anogenital cancer is now supported by such overwhelming evidence that even the most sceptical critic of a virus/cancer hypothesis must take note. Nevertheless, when the data are examined objectively, it becomes clear that as with so many, perhaps all, cancer etiologies that have been studied, more than one factor is involved in the progression to malignancy. HPV may be the major player in this disease, may be necessary to initiate and maintain the process, but for the eventual manifestation of invasive carcinoma may not be sufficient. In vitro studies of the effects of HPV gene expression on primary human cells in culture have provided a basis for evaluation of the phenotypic changes resulting from interaction of the viral gene products with cellular genes.