Symptoms in patients with lowered levels of IgG subclasses, with or without IgA deficiency, and effects of immunoglobulin prophylaxis.
Symptoms in patients with lowered levels of IgG subclasses, with or without IgA deficiency, and effects of immunoglobulin prophylaxis.
复制标题
IgG 亚类水平降低、伴或不伴 IgA 缺乏的患者的症状，以及免疫球蛋白预防的效果。
DOI：
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发表时间：
1986
期刊：
影响因子：
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通讯作者：
L. Hanson
中科院分区：
文献类型：
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作者：
J. Björkander;U. Bengtsson;V. Oxelius;L. Hanson
一些 IgG 亚类水平低于正常水平的患者存在反复感染。需要进一步的对照研究来更好地确定各个亚类的水平与可能的临床后果之间的关系。确定 IgG 亚类缺乏是否会导致导致肺损伤的感染可能很重要，正如少数 IgA 缺乏且 IgG 亚类水平较低的患者所建议的那样。一项公开研究对 38 名 IgG 亚类 1、2 或 3 中的一种或两种水平低于正常的患者进行了免疫球蛋白预防效果的研究，在总共 1,524 个月的观察期间表明，其中许多人的情况得到了改善。这必须在仔细对照的研究中得到进一步证实。免疫球蛋白预防可以对 IgG 亚类缺陷且 IgA 缺乏和抗 IgA 抗体的患者进行，只要使用 IgA 含量低的制剂并且患者的抗 IgA 滴度在预防期间不增加。
Several patients with subnormal levels of IgG subclasses have repeated infections. Further controlled studies are required to better define the relation between the level of the various subclasses and the possible clinical consequences. It may be important to determine whether or not IgG subclass deficiency can lead to infections which cause lung damage as was suggested in a few patients with IgA deficiency combined with low IgG subclass levels. An open study of the effect of immunoglobulin prophylaxis in 38 patients with subnormal levels of one or two of the IgG subclasses 1, 2 or 3 during altogether 1,524 months of observation suggested that many of them improved. This must be further substantiated in carefully controlled studies. Immunoglobulin prophylaxis could be given in IgG subclass deficient patients with IgA deficiency and anti-IgA antibodies, provided a preparation poor in IgA was used and the patients' anti-IgA titres did not increase during the prophylaxis.