TREATMENT OF IDIOPATHIC MIXED CRYOGLOBULINEMIA WITH ALPHA-INTERFERON
TREATMENT OF IDIOPATHIC MIXED CRYOGLOBULINEMIA WITH ALPHA-INTERFERON
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DOI：
10.1016/0002-9343(87)90904-1
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发表时间：
1987-10-01
影响因子：
5.9
通讯作者：
CACCAVO, D
中科院分区：
文献类型：
--
作者：
BONOMO, L;CASATO, M;CACCAVO, D
7例II型特发性混合冷球蛋白血症患者接受重组人白细胞干扰素（α干扰素）治疗。在所有这些患者中，循环cryopulins明显减少，临床模式明显改善。免疫学参数（自然杀伤细胞活性和吞噬作用等）也得到改善;副作用通常是轻微和短暂的。在少数情况下，发生在cryopulin水平的增加，但他们至少是部分敏感的α干扰素治疗再给药。在这些特发性冷球蛋白血症病例中获得的有利结果似乎是一致的和长期的。
Seven patients with type II idiopathic mixed cryoglobulinemia were treated with recombinant human leukocyte interferon (alpha interferon). In all of them, a conspicuous reduction of circulating cryoglobulins was noted, together with a definite, remarkable improvement of the clinical pattern. The immunologic parameters (natural killer cell activity and phagocytosis, among others) improved as well; side effects were usually mild and transient. Increases in the cryoglobulin level occurred in a few cases, but they were at least partly sensitive to readministration of alpha interferon treatment. The favorable results obtained in these cases of idiopathic cryoglobulinemia seem to be consistent and prolonged.