Depression and cardiovascular disease: Mechanisms of interaction
Depression and cardiovascular disease: Mechanisms of interaction
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DOI：
10.1016/s0006-3223(03)00568-7
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发表时间：
2003-08-01
影响因子：
10.6
通讯作者：
O'Connor, CM
中科院分区：
文献类型：
--
作者：
Joynt, KE;Whellan, DJ;O'Connor, CM
本文从机制角度探讨抑郁症与心血管疾病的关系。抑郁症和心血管疾病是美国最普遍的两个健康问题，也是美国和世界范围内致残的两个主要原因。虽然抑郁症是已知的心血管疾病发展的危险因素，也是心脏事件后预后不良的独立预测因素，但两者之间的机制关系尚不清楚。抑郁症与个人健康状况的变化有关，这些变化可能影响心血管疾病的发展和病程，包括不遵守医疗建议，以及存在心血管风险因素，如吸烟和高血压。此外，抑郁症还与生理变化有关，包括神经系统激活、心律紊乱、全身和局部炎症以及高凝性，这些都会对心血管系统产生负面影响。此外，压力可能是导致抑郁症和心血管疾病发展的潜在诱因。本文综述了抑郁症与心血管疾病之间关系的七种潜在机制，并介绍了每种机制的现有证据。最后，对今后的研究方向进行了展望。(C) 2003年生物精神病学学会。
This article explores the relationship between depression and cardiovascular disease from a mechanistic standpoint. Depression and cardiovascular disease are two of the most prevalent health problems in the United States and are the two leading causes of disability both in the United States and worldwide. Although depression is a known risk factor for the development of cardiovascular disease, as well as an independent predictor of poor prognosis following a cardiac event, the mechanistic relationship between the two remains unclear. Depression is associated with changes in an individual's health status that may influence the development and course of cardiovascular disease, including noncompliance with medical recommendations, as well as the presence of cardiovascular risk factors such as smoking and hypertension. In addition, depression is associated with physiologic changes, including nervous system activation, cardiac rhythm disturbances, systemic and localized inflammation, and hypercoagulability, that negatively influence the cardiovascular system. Further, stress may be an underlying trigger that leads to the development of both depression and cardiovascular disease. This article reviews seven potential mechanisms for the relationship between depression and cardiovascular disease and presents the available evidence surrounding each mechanism. Finally, future directions for research are discussed. (C) 2003 Society of Biological Psychiatry.