Interleukin-1β production in dysthymia before and after pharmacotherapy
Interleukin-1β production in dysthymia before and after pharmacotherapy
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DOI：
10.1016/s0006-3223(99)00211-5
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发表时间：
1999-12-15
影响因子：
10.6
通讯作者：
Merali, Z
中科院分区：
文献类型：
--
作者：
Anisman, H;Ravindran, AV;Merali, Z
背景资料：重性抑郁症一样，心境恶劣已与有丝分裂原刺激的淋巴细胞中的白细胞介素-1（IL-1 β）的产生升高，在本调查中，我们评估是否升高的IL-1 β在心境恶劣患者生产将正常化以下治疗与舍曲林。方法：IL-1 β的生产测定在心境恶劣患者和非抑郁症对照组。然后，患者接受12周的剂量的舍曲林或安慰剂的双盲试验，在此之后，细胞因子的生产再次determinedResults：基础IL-1 β升高，心境恶劣患者相对于对照组。细胞因子的产生与症状的严重程度和发病年龄适度相关。相对于安慰剂治疗，舍曲林减轻了抑郁症的症状;然而，这并不伴随着IL-1 β产生的正常化。虽然心境恶劣与IL-1 β产生升高有关，但症状缓解后细胞因子未能正常化表明IL-1 β可能是疾病的性状标志物，或者需要更持续的治疗来减少细胞因子的产生。鉴于外源性给予IL-1 β的神经内分泌和中枢神经化学后果，应探讨IL-1 β产生增加可能在恶劣心境的病理生理学中发挥作用的可能性。生物精神病学1999;46：1649-1655（C）1999年生物精神病学学会。
Background: Like major depression, dysthymia has been associated with elevated production of interleukin-1 (IL-1 beta) in mitogen-stimulated lymphocytes, In the present investigation, we assessed whether the elevated IL-I beta production in dysthymic patients would normalize following treatment with sertraline.Methods: The production of IL-I beta was determined in dysthymic patients and in nondepressed control subjects. Patients then received 12 weeks of doses of either sertraline or placebo in a double-blind trial, after which cytokine production was again determinedResults: Basal IL-I beta was elevated in dysthymic patients relative to control subjects. Cytokine production was modestly correlated with the severity of symptoms and with the age of illness onset. Relative to placebo treatment, sertraline attenuated the symptoms of depression; however, this was not accompanied by normalization of IL-1 beta production.Conclusions: While dysthymia is associated with elevated IL-I beta production, the failure for the cytokine to normalize following symptom alleviation suggests that either the IL-I beta may be a trait marker of the illness, or that more sustained treatment is necessary to reduce cytokine production. Given the neuroendocrine and central neurochemical consequences of exogenously administered IL-1 beta, the possibility ought to be explored that increased IL-I beta production may play a role in the pathophysiology of dysthymia. Biol Psychiatry 1999;46:1649-1655 (C) 1999 Society of Biological Psychiatry.