Different aberrant expression pattern of immune checkpoint receptors in patients with PTCL and NK/T-CL
Different aberrant expression pattern of immune checkpoint receptors in patients with PTCL and NK/T-CL
复制标题
PTCL和NK/T-CL患者免疫检查点受体的不同异常表达模式
DOI：
10.1111/ajco.12850
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发表时间：
2018-10-01
影响因子：
1.9
通讯作者：
Li，Yangqiu
中科院分区：
文献类型：
--
作者：
Liao，Ziwei;Lv，Xuewen;Li，Yangqiu
AimTo better understand the T‐cell immunodeficiency status in patients with peripheral T‐cell lymphomas (PTCLs) and NK/T‐cell lymphomas (NK/T‐CLs), the T‐cell inhibitory receptors expression pattern was investigated.MethodsThe expression levels of programmed death 1 (PD‐1), cytotoxic T lymphocyte‐associated antigen 4 (CTLA‐4), B/T lymphocyte attenuator (BTLA), lymphocyte‐activation gene 3 (LAG‐3), T‐cell immunoglobulin‐3 (TIM‐3), T‐cell immunoglobulin and ITIM domain (TIGIT) genes were detected in peripheral blood mononuclear cells (PBMCs) from patients and healthy volunteers by quantitative real‐time‐PCR, the correlation between different gene expression levels was analyzed.ResultsSignificantly higher expression ofPD‐1, CTLA‐4, BTLA, LAG‐3, TIM‐3andTIGITcan be observed as a common characteristic in patients with PTCL or NK/T‐CL. However, the coexpression pattern seemed different between subtypes. Their overexpression is also related to disease progression stage.ConclusionWe first characterized the expression pattern of six T‐cell inhibitory receptor genes in PTCL and NK/T‐CL, which might work as immune biomarkers for evaluation the immunosuppression status and help to establish the precision targets of immunotherapy.
