INTEGRINS AND CELL-ADHESION MOLECULES - NEURONAL RECEPTORS THAT REGULATE AXON GROWTH ON EXTRACELLULAR MATRICES AND CELL-SURFACES
INTEGRINS AND CELL-ADHESION MOLECULES - NEURONAL RECEPTORS THAT REGULATE AXON GROWTH ON EXTRACELLULAR MATRICES AND CELL-SURFACES
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DOI：
10.1159/000111910
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发表时间：
1989-01-01
影响因子：
2.9
通讯作者：
TOMASELLI, KJ
中科院分区：
文献类型：
--
作者：
REICHARDT, LF;BIXBY, JL;TOMASELLI, KJ
激发我们研究的核心问题是了解神经元如何将过程延伸到其目标并在发育和再生过程中建立适当的突触。一种类型的神经元在不同的胚胎中可重复地发育，并且其细胞外环境中的分子对于指导这种发育的大部分过程显然很重要。特别是，调节生长锥运动的分子被认为在特定轴突通路的建立中发挥核心作用。在脊椎动物和无脊椎动物物种中，生长锥受到与其他神经元和非神经元细胞的表面和分泌产物的接触的影响[参见Bentley和Caudy，1983；拉珀等人，1984； Kapfhammerand Raper，1987]，发育神经生物学的一个主要挑战是识别这些分子及其神经元受体。
The central question that motivates our research is to understand how neurons ex tend processes to their targets and establish appropriate synapses during development and regeneration. Neurons of one type de velop reproducibly in different embryos, and molecules in their extracellular environment are clearly important for directing much of this development. In particular, molecules that regulate growth cone motility are be lieved to play a central role in the establish ment of specific axonal pathways. In both vertebrate and invertebrate species, growth cones are influenced by contacts with the sur faces and secreted products of other neuronal and nonneuronal cells [see Bentley and Caudy, 1983; Râper et al., 1984; Kapfhammerand Raper, 1987], A major challenge in developmental neurobiology is to identify these molecules and their neuronal recep tors.