Mycoplasma genitalium is not associated with adverse outcomes of pregnancy in Guinea-Bissau
Mycoplasma genitalium is not associated with adverse outcomes of pregnancy in Guinea-Bissau
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DOI：
10.1136/sti.78.4.289
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发表时间：
2002-08-01
影响因子：
3.6
通讯作者：
Pépin, J
中科院分区：
文献类型：
--
作者：
Labbé, AC;Frost, E;Pépin, J
目的：探讨生殖道支原体感染对妊娠结局的影响。方法：使用聚合酶链反应（PCR）方法检测生殖器M的存在，这些宫颈样本来自以前参加过病例对照研究（旨在评估梅毒和HIV-2对几内亚比绍妊娠结局的影响）的妇女。对照组是分娩过出生体重超过2500克的足月新生儿的妇女。病例根据妊娠结局分为四组：死产、自然流产、早产和小于胎龄（SGA）婴儿。结果：本研究纳入的1014名妇女中，6.2%感染了生殖器M。生殖器感染与妊娠的任何不良结果均无显著相关性。存在生殖器M感染的早产或SGA分娩的优势比（OR）分别为1.37 （95% CI 0.69至2.60）和0.44 （95% CI 0.01至2.75）。流产和死产的OR分别为0.61 （95% CI 0.07 ~ 2.51）和1.07 （95% CI 0.42 ~ 2.42）。结论：生殖器M对妊娠结局无不良影响。
Objective: To evaluate the impact of Mycoplasma gentialium on the outcome of preganancy.Methods: Cervical samples from women who had previously participated in a case-control study (designed to assess the impact of syphilis and HIV-2 on the outcome of pregnancy in Guinea-Bissau) were processed using a PCR assay to detect the presence of M genitalium. Controls were women who had delivered a term neonate with a birth weight over 2500 g. Cases were classified into four groups of mothers according to the outcome of pregnancy: stillbirths, spontaneous abortions, premature deliveries, and small for gestational age (SGA) babies.Results: Among the 1014 women included in this study, 6.2% were infected with M genitalium. M genitalium infection was not significantly associated with any of the adverse outcomes of pregnancy studied. Odds ratios (OR) for premature or SGA delivery in the presence of M genitalium infection wre 1.37 (95% CI 0.69 to 2.60) and 0.44 (95% CI 0.01 to 2.75), respectively. For abortions and stillbirths, OR were respectively 0.61 (95% CI 0.07 to 2.51) and 1.07 (95% CI 0.42 to 2.42).Conclusion: M genitalium appears not to have a deleterious impact on the outcome of pregnancy.