The putative cell receptors for hepatitis B virus (HBV), annexin V, and apolipoprotein H, bind to lipid components of HBV.
The putative cell receptors for hepatitis B virus (HBV), annexin V, and apolipoprotein H, bind to lipid components of HBV.
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DOI：
10.1006/viro.1994.1558
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发表时间：
1994-10
期刊：
影响因子：
3.7
通讯作者：
A. Neurath;N. Strick
中科院分区：
文献类型：
--
作者：
A. Neurath;N. Strick
据报道，膜联蛋白V和载脂蛋白H可结合B型肝炎表面抗原（HBsAg），并推测与HBsAg S蛋白特异性反应，在启动B型肝炎病毒感染中起重要作用，但不与脱脂HBsAg（dlHBsAg）结合。通过向dlHBsAg添加脂质来恢复结合活性。这些结果与膜联蛋白V和载脂蛋白H对脂质的既定亲和力一致。
Annexin V and apolipoprotein H, reported to bind hepatitis B surface antigen (HBsAg) and presumed to react specifically with the HBsAg S protein and to play an important role in initiation of infection by hepatitis B virus, did not bind to delipidated HBsAg (dlHBsAg). Binding activity was restored by adding lipids to dlHBsAg. These results are consistent with the established affinity of annexin V and apolipoprotein H for lipids.