Left ventricular dysfunction of isolated working rat hearts after chronic alcohol consumption.
Left ventricular dysfunction of isolated working rat hearts after chronic alcohol consumption.
复制标题
长期饮酒后离体工作大鼠心脏的左心室功能障碍。
DOI：
10.1093/cvr/13.3.136
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发表时间：
1979
影响因子：
10.8
通讯作者：
D. Mason
中科院分区：
文献类型：
--
作者：
L. D. Segel;S. Rendig;D. Mason
本文研究了慢性酒精中毒大鼠和对照大鼠离体灌流工作心脏的机械、血流动力学和能量功能。雄性Long-Evans大鼠喂食营养全面的流质饮食，其中乙醇占每日卡路里的38%（对照组用糊精-麦芽糖进行等热量替代），持续34至48周。酗酒者和对照组从脂肪中获得7.4%（低脂）或21.0%（高脂）的热量。通过干心脏重量匹配动物以进行比较，并在改进的隔离喷射心脏灌注制备中以恒定心率评价心脏。心室功能曲线和对10（-7）mol . L-1盐酸多巴酚丁胺在常氧和低氧灌注。在常氧条件下，高脂和低脂酒精组动物的心脏对多巴酚丁胺的左室最大收缩压、左室最大压力上升率和最大射血速度的反应均显著低于对照组。在低氧条件下，低脂肪酒精心脏的左心室最大收缩压略低于低脂肪对照心脏的最大收缩压，但在三种充盈压下均显著低于低脂肪对照心脏。此外，在缺氧时，多巴酚丁胺对酒精性心脏的左心室最大压力上升率的增加明显低于对照组。这些数据表明，长期饮用适量的酒精，即使沿着营养充足的饮食，也会导致心肌收缩力和泵功能下降，这在心脏处于应激状态时可能会表现出来。
The mechanical, haemodynamic, and energetic functions of isolated perfused working hearts from chronic alcoholic and control rats were studied. Male Long-Evans rats were fed a nutritionally-complete liquid diet containing 38% of daily calories as ethanol (isocaloric replacement with dextrin-maltose for controls) for 34 to 48 weeks. Alcoholics and controls received either 7.4% (low-fat) or 21.0% (high-fat) of calories from lipid. Animals were matched by dry heart weight for comparisons and hearts were evaluated at a constant heart rate in an improved isolated ejecting heart perfusion preparation. Ventricular function curves and the response to 10(-7) mol . litre-1 dobutamine HCl were obtained during normoxic and hypoxic perfusion. In normoxia, the hearts from the high- and low-fat alcoholic animals exhibited a significantly lower response of left ventricular maximum systolic pressure, left ventricular maximum rate of pressure rise and maximum ejection velocity to dobutamine than did the controls. In hypoxia, the left ventricular maximum systolic pressure of the low-fat alcoholic hearts was slightly, but significantly, lower than that of the low-fat control hearts at the three filling pressures studied. Also in hypoxia, the increase in left ventricular maximum rate of pressure rise with dobutamine was significantly less in the alcoholic hearts than in controls. These data suggest that long-term consumption of moderate amounts of alcohol even along with a nutritionally-adequate diet can result in depressed myocardial contractility and pump function that may be manifest when the heart is subjected to stress conditions.