HEPATIC GLUCOSE-PRODUCTION AND INSULIN SENSITIVITY AND RESPONSIVENESS IN IRON-DEFICIENT ANEMIC RATS
HEPATIC GLUCOSE-PRODUCTION AND INSULIN SENSITIVITY AND RESPONSIVENESS IN IRON-DEFICIENT ANEMIC RATS
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DOI：
10.1152/ajpendo.1993.264.3.e380
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发表时间：
1993-03-01
影响因子：
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通讯作者：
FARRELL, PA
中科院分区：
文献类型：
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作者：
BOREL, MJ;BEARD, JL;FARRELL, PA
我们在1.9、4.0、9.3和19.3 mU的胰岛素输注速率下进行了正常血糖高胰岛素葡萄糖钳夹。kg-1 . min-1，以评估IDA对胰岛素敏感性和反应性的影响。使用预充的[3-H-3]葡萄糖连续输注测定葡萄糖出现和消失（R（d））率。IDA和对照组大鼠的基础血糖和胰岛素浓度相似。在两个贫血最严重的组中，基础肝葡萄糖生成显著（P = 0.0001）升高（13.6 +/- 2.4和12.6 +/- 3.1 vs. 10.6 +/- 2.2和10.2 +/- 2.0 mg.kg-1.min-1）。R（d）的胰岛素剂量-反应曲线显著上移表明两个最严重贫血组的外周胰岛素反应性增加，而轻微上移表明所有三个贫血组的胰岛素敏感性增加。肝脏胰岛素敏感性和反应性不受IDA的影响。我们得出结论，IDA大鼠葡萄糖利用率的增加主要是由于外周胰岛素反应性的增加。
We performed euglycemic hyperinsulinemic glucose clamps at insulin infusion rates of 1.9, 4.0, 9.3, and 19.3 mU . kg-1 . min-1 in rats with varying severities of iron deficiency anemia (IDA; mean hemoglobin concentrations of 59, 79, 107, and 137 g/l) to assess the effect of IDA on insulin sensitivity and responsiveness. Glucose appearance and disappearance (R(d)) rates were determined using a primed continuous infusion of [3-H-3]glucose. Basal plasma glucose and insulin concentrations were similar between the IDA and control rats. Basal hepatic glucose production was significantly (P = 0.0001) elevated in the two most anemic groups (13.6 +/- 2.4 and 12.6 +/- 3.1 vs. 10.6 +/- 2.2 and 10.2 +/- 2.0 mg.kg-1.min-1). A significant upward shift in the insulin dose-response curves for R(d) indicated an increase in peripheral insulin responsiveness in the two most anemic groups while a slight leftward shift was suggestive of an increase in insulin sensitivity in all three anemic groups. Hepatic insulin sensitivity and responsiveness were unaffected by IDA. We conclude that increased glucose utilization rates in IDA rats are due primarily to an increase in peripheral insulin responsiveness.