Silver-Catalyzed Decarboxylative Allylation of Aliphatic Carboxylic Acids in Aqueous Solution
Silver-Catalyzed Decarboxylative Allylation of Aliphatic Carboxylic Acids in Aqueous Solution
复制标题
水溶液中银催化脂肪族羧酸的脱羧烯丙基化
DOI：
10.1021/acs.orglett.6b00802
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发表时间：
2016-05-06
期刊：
影响因子：
5.2
通讯作者：
Li, Chaozhong
中科院分区：
文献类型：
--
作者：
Cui, Lei;Chen, He;Li, Chaozhong
描述了脂肪族羧酸的直接脱羧自由基烯丙基化。以K2S2O8为氧化剂，AgNO3为催化剂，脂肪族羧酸与烯丙基反应。在温和条件下，CH3CN水溶液中的砜以令人满意的收率得到相应的烯烃。这种位点特异性烯丙基化方法适用于所有伯、仲和叔烷基酸，并表现出广泛的官能团兼容性。
Direct decarboxylative radical allylation of aliphatic carboxylic acids is described. With K2S2O8 as the oxidant and AgNO3 as the catalyst, the reactions of aliphatic carboxylic acids with allyl. sulfones in aqueous CH3CN solution gave the corresponding alkenes in satisfactory yields under mild conditions. This site-specific allylation method is applicable to all primary, secondary, and tertiary alkyl acids and exhibits wide functional group compatibility.