β-cell apoptosis in type 2 diabetes:: Quantitative and functional consequences
β-cell apoptosis in type 2 diabetes:: Quantitative and functional consequences
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DOI：
10.1016/s1262-3636(08)73396-2
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发表时间：
2008-02-01
影响因子：
7.2
通讯作者：
Del Prato, S.
中科院分区：
文献类型：
--
作者：
Lupi, R.;Del Prato, S.
2型糖尿病是人类最常见的糖尿病形式，其特征是胰岛素分泌受损，同时伴随着β细胞功能的进行性下降和慢性胰岛素抵抗。几位作者已经证明，在2型糖尿病患者中，胰岛和/或含有胰岛素的细胞团或体积减少。β细胞质量的调节似乎涉及到β细胞复制和凋亡的平衡，但在分子水平上，胰腺β细胞因凋亡而丢失似乎在胰岛素缺乏的发展和疾病的发生和/或进展中起着重要作用。本文讨论了2型糖尿病胰岛细胞凋亡的机制，以及预防胰岛β细胞死亡和维持胰岛β细胞质量的新的潜在治疗方法。(C)2008年，爱思唯尔·马森公司。版权所有。
Type 2 diabetes, the most common form of diabetes in humans, is characterized by impaired insulin secretion paralleled by a progressive decline in beta-cell function and chronic insulin resistance. Several authors have showed that in type 2 diabetes there is a reduction of islet and/or insulin-containing cell mass or volume. Regulation of the beta-cell mass appears to involve a balance of beta-cell replication and apoptosis but, at the molecular level, pancreatic beta-cell loss by apoptosis appears to play an important role in the development of insulin deficiency and the onset and/or progression of the disease. The mechanisms favoring apoptosis in type 2 diabetic pancreatic islets and new potential therapeutic approaches to prevent beta-cell death and maintain beta-cell mass are discussed. (C) 2008, Elsevier Masson SAS. All rights reserved.