Impact of the Interaction Between the 5HTTLPR Polymorphism and Maltreatment on Adolescent Depression. A Population-Based Study
Impact of the Interaction Between the 5HTTLPR Polymorphism and Maltreatment on Adolescent Depression. A Population-Based Study
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DOI：
10.1007/s10519-009-9285-9
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发表时间：
2009-09-01
影响因子：
2.6
通讯作者：
Nilsson, Kent W.
中科院分区：
文献类型：
--
作者：
Aslund, Cecilia;Leppert, Jerzy;Nilsson, Kent W.
血清素在情绪调节和抑郁症的发展中起着重要作用。本研究探讨了5-羟色胺转运体基因的功能多态性（5 HTTLPR）是否与虐待在预测抑郁症中相互作用。一组17-18岁的学生（n = 1，482）匿名完成了2006年维斯曼兰青少年生活和健康调查，并提供了唾液样本用于DNA提取。虐待和青少年抑郁症之间的关联被发现独立于性别。当对整个人群进行分析时，没有发现5 HTTLPR与抑郁症相关的主效应，当按性别分开时，在女孩中发现SS等位基因的显著主效应和G × E交互效应。在男生中未发现基因主效应或G × E互作效应。本研究证实了以前的研究结果，性别差异之间的交互作用的影响5 HTTLPR多态性和虐待的预测青少年抑郁症。
Serotonin plays a central role in mood regulation and the development of depressive disorders. The present study investigated whether a functional polymorphism (5HTTLPR) of the serotonin transporter gene interacts with maltreatment in the prediction of depression. A cohort of 17-18 years old students (n = 1,482) anonymously completed the Survey of Adolescent Life and Health in Vestmanland 2006 and gave a saliva sample for DNA extraction. An association between maltreatment and adolescent depression was found independent of sex. When the whole population was analyzed, no main effect of 5HTTLPR in association with depression was found. When separated by sex, a significant main effect and a G x E interaction effect of the SS allele was found among girls. No gene main effect or G x E interaction effect was found among boys. The present study confirms previous findings of sex differences in interaction effects between the 5HTTLPR polymorphism and maltreatment in the prediction of adolescent depression.