The neuropsychological profile of psychotic major depression and its relation to cortisol
The neuropsychological profile of psychotic major depression and its relation to cortisol
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DOI：
10.1016/j.biopsych.2005.11.010
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发表时间：
2006-09-01
影响因子：
10.6
通讯作者：
Schatzberg, Alan F.
中科院分区：
文献类型：
--
作者：
Gomez, Rowena G.;Fleming, Shelley H.;Schatzberg, Alan F.
背景资料：我们的研究描述了精神病性抑郁症（PMD）与非精神病性抑郁症（NPMD）患者和精神健康对照（HC）的神经心理学特征。我们预测，较高的皮质醇水平将与更大的认知缺陷。在斯坦福大学医学中心招募了29名PMD、24名NPMD和26名HC。获得精神病学评分、1800-0900小时皮质醇水平和神经心理学测试数据。与NPMD和HCs相比，PMD的认知障碍更严重，但简单的言语注意除外。PMD的平均皮质醇水平升高，从1800至0100小时，这是显着相关的文字记忆和心理速度性能较差。1800至0100小时的皮质醇斜率也与言语记忆和工作记忆显着相关。结论。如果PMD被动地接受信息诉求的能力完好无损，他们在处理、操纵和编码新信息方面就有更多的困难。皮质醇水平升高，如PMD患者所见，与认知能力较差有关，特别是与单词列表和工作记忆的非文字记忆有关。
Background: Our study described the neuropsycbological profile of psychotic major depression (PMD) compared to nonpsycbotic major depression (NPMD) patients and psychiatrically healthy controls (HC). We predicted that higher cortisol levels would be associated with greater cognitive deficits.Methods. Twenty-nine PMDs, 24 NPMDs, and 26 HCs were recruited at Stanford University Medical Center. Psychiatric ratings, cortisol levels from 1800-0900 hours, and neuropsycbological test data were obtained.Results. PMDs bad more severe cognitive impairments compared with NPMDs and HCs with the exception of simple verbal attention. PMDs had elevated mean cortisol levels from 1800 to 0100 hours which were significantly correlated with poorer verbal memory and psychomotor speed performance. Cortisol slopes from 1800 to 0100 hours were also significantly correlated with verbal memory and working memory.Conclusions. Wbile PMD's ability to attendpassively to information appeal's intact, they have more difficulty processing, manipulating, and encoding new information. Elevated cortisol levels, as seen in PMD patients, are associated with poorer cognitive performance especially related to verbal memory for lists of words and working memory.