The Geriatric Nutritional Risk Index Predicts Survival in Elderly Esophageal Squamous Cell Carcinoma Patients with Radiotherapy.
The Geriatric Nutritional Risk Index Predicts Survival in Elderly Esophageal Squamous Cell Carcinoma Patients with Radiotherapy.
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DOI：
10.1371/journal.pone.0155903
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发表时间：
2016
期刊：
影响因子：
3.7
通讯作者：
Yuan L
中科院分区：
文献类型：
--
作者：
Bo Y;Wang K;Liu Y;You J;Cui H;Zhu Y;Lu Q;Yuan L
营养状况对接受放射治疗的老年食管鳞癌(ESCC)患者生存率的影响尚不清楚。在这项研究中，我们旨在验证老年营养风险指数(GNRI)在预测接受放射治疗的老年ESCC患者总体生存时间方面的表现。对2008-01/2014-11河南省肿瘤医院(郑州大学附属肿瘤医院)放疗科连续收治的239例60岁及以上食管癌患者进行了回顾性队列研究，中国。所有患者都接受了GNRI营养筛查，并随访了淋巴转移、放射并发症和死亡率的发生。生存曲线估计采用Kaplan-Meier法，Log-ranch检验。采用单变量COX回归分析确定与总生存时间相关的变量。239例患者中，184例(76.9%)无营养风险，32例(13.4%)有中度营养不良风险，23例(9.7%)有高度营养不良风险。单因素COX回归分析显示，高营养风险组和中等营养风险组的生存风险均显著低于无营养风险组(风险比HR=1.688，95%可信区间1.019~2.798；高风险组HR=2.699，95%CI=1.512~4.819)。GNRI是影响接受放射治疗的老年ESCC患者总体生存时间的独立预后因素。GNRI≤98可以作为存活时间较短的指标。
The impact of nutritional status on survival among elderly esophageal squamous cell carcinoma (ESCC) patients undergoing radiotherapy is unclear. In this study, we aimed at validating the performance of the geriatric nutritional risk index (GNRI) in predicting overall survival time in elderly ESCC patients with radiotherapy. A retrospective cohort study was conducted on 239 ESCC patients aged 60 and over admitted consecutively from January 2008 to November 2014 in the Department of Radiotherapy, Henan Tumor Hospital (Affiliated Tumor Hospital of Zhengzhou University), Zhengzhou, Henan, China. All patients were subjected to nutritional screening using GNRI, and were followed for the occurrence of lymphatic node metastasis, radiation complication and mortality. The Kaplan–Meier method with Log-rank test was used to estimate survival curves. Univariable Cox regression analysis was used to identify variables associated with overall survival time. Among the 239 patients, 184 patients (76.9%) took no nutritional risk, 32 patients (13.4%) took moderate risk of malnutrition, and 23 patients (9.7%) took a high risk of malnutrition. Univariable Cox regression showed that both high nutritional risk group and moderate nutritional risk group were significantly less likely to survive than no nutritional risk patients (hazard ratio (HR) = 1.688, 95% confidence interval (CI) = 1.019–2.798 for moderate risk group, and HR = 2.699, 95% CI = 1.512–4.819 for high risk group, respectively). The GNRI is an independent prognostic factor for overall survival time in elderly ESCC patients with radiotherapy. A GNRI ≤98 can be suggested as an indicator of surviving less.