Leukocyte margination at arteriole shear rate.
Leukocyte margination at arteriole shear rate.
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DOI：
10.14814/phy2.12037
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发表时间：
2014-06-01
影响因子：
2.5
通讯作者：
Ishikawa T
中科院分区：
文献类型：
--
作者：
Takeishi N;Imai Y;Nakaaki K;Yamaguchi T;Ishikawa T
我们数值研究了直径为10 ~ 22 μm的直圆形通道中白细胞在微动脉切变率下的边集。我们的研究结果表明，通过运动的红细胞有效地诱导白细胞边集不仅在小通道，而且在大通道。在较大的通道中发生边集需要较长的时间，但是一旦白细胞边集，RBC的通过运动连续发生，与通道直径无关，并且白细胞边集持续较长的持续时间。我们还表明，白细胞很少接近壁表面内微绒毛长度在小动脉剪切率。我们数值研究了直径范围为10至22 µm的直圆形通道中微动脉剪切速率下白细胞的边集。我们的研究结果表明，通过运动的红细胞有效地诱导白细胞边集不仅在小通道，而且在大通道。我们还表明，白细胞很少接近壁表面内微绒毛长度在小动脉剪切率。
We numerically investigated margination of leukocytes at arteriole shear rate in straight circular channels with diameters ranging from 10 to 22 μm. Our results demonstrated that passing motion of RBCs effectively induces leukocyte margination not only in small channels but also in large channels. A longer time is needed for margination to occur in a larger channel, but once a leukocyte has marginated, passing motion of RBCs occurs continuously independent of the channel diameter, and leukocyte margination is sustained for a long duration. We also show that leukocytes rarely approach the wall surface to within a microvillus length at arteriole shear rate. We numerically investigated margination of leukocytes at arteriole shear rate in straight circular channels with diameters ranging from 10 to 22 µm. Our results demonstrated that passing motion of RBCs effectively induces leukocyte margination not only in small channels but also in large channels. We also show that leukocytes rarely approach the wall surface to within a microvillus length at arteriole shear rate.