Axonal Sprouting and Formation of Terminals in the Adult Cerebellum during Associative Motor Learning
Axonal Sprouting and Formation of Terminals in the Adult Cerebellum during Associative Motor Learning
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DOI：
10.1523/jneurosci.0511-13.2013
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发表时间：
2013-11-06
影响因子：
5.3
通讯作者：
Ruigrok, Tom J. H.
中科院分区：
文献类型：
--
作者：
Boele, Henk-Jan;Koekkoek, Sebastiaan K. E.;Ruigrok, Tom J. H.
突触功效的可塑性变化被广泛认为是记忆形成的基础机制。到目前为止，学习依赖的新神经元布线的证据是有限的。在这项研究中，我们证明了巴甫洛夫眨眼条件反射在成年小鼠可以诱导强大的轴突生长和突触形成小脑核。这种从头布线是条件特异性和区域特异性的，因为它不会发生在假条件动物中，并且特别是在小脑核的那些部分中观察到，这些部分涉及这种形式的运动学习。此外，在小脑核的这些部分中的新的苔藓纤维静脉曲张的数量与条件眼睑反应的幅度呈正相关。这些结果表明，轴突的生长和伴随出现的新的终端可能，除了可塑性的突触效能，有助于记忆的形成。
Plastic changes in the efficacy of synapses are widely regarded to represent mechanisms underlying memory formation. So far, evidence for learning-dependent, new neuronal wiring is limited. In this study, we demonstrate that pavlovian eyeblink conditioning in adult mice can induce robust axonal growth and synapse formation in the cerebellar nuclei. This de novo wiring is both condition specific and region specific because it does not occur in pseudoconditioned animals and is particularly observed in those parts of the cerebellar nuclei that have been implicated to be involved in this form of motor learning. Moreover, the number of new mossy fiber varicosities in these parts of the cerebellar nuclei is positively correlated with the amplitude of conditioned eyelid responses. These results indicate that outgrowth of axons and concomitant occurrence of new terminals may, in addition to plasticity of synaptic efficacy, contribute to the formation of memory.