Vestibulo-Ocular Reflex Responses to a Multichannel Vestibular Prosthesis Incorporating a 3D Coordinate Transformation for Correction of Misalignment
Vestibulo-Ocular Reflex Responses to a Multichannel Vestibular Prosthesis Incorporating a 3D Coordinate Transformation for Correction of Misalignment
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DOI：
10.1007/s10162-010-0208-5
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发表时间：
2010-09-01
影响因子：
2.4
通讯作者：
Della Santina, Charles C.
中科院分区：
文献类型：
--
作者：
Fridman, Gene Y.;Davidovics, Natan S.;Della Santina, Charles C.
对于无法弥补双侧严重前庭感觉丧失的个人来说，目前还没有有效的治疗方法，这种感觉会导致慢性平衡失调，并通过扰乱在头部运动期间通常稳定眼睛的前庭-眼睛反射而模糊视力。以前的工作表明，多通道前庭假体可以通过电刺激前庭神经分支来编码安装在头骨上的相互垂直的陀螺仪检测到的头部运动，从而模拟正常的半规管。到目前为止，这种方法一直受到电流传播的限制，导致前庭神经激活模式扭曲，从而无法准确编码通常由迷路传递的整个三维(3D)范围内的头部运动。我们报道，电诱发的3D角度前庭-眼反射表现出足够的矢量叠加和线性，以至于多通道前庭假体结合预代偿3D坐标变换来纠正对准错误，可以在正常迷宫转换的3D轴范围内准确地模拟头部旋转的半规管。
There is no effective treatment available for individuals unable to compensate for bilateral profound loss of vestibular sensation, which causes chronic disequilibrium and blurs vision by disrupting vestibulo-ocular reflexes that normally stabilize the eyes during head movement. Previous work suggests that a multichannel vestibular prosthesis can emulate normal semicircular canals by electrically stimulating vestibular nerve branches to encode head movements detected by mutually orthogonal gyroscopes affixed to the skull. Until now, that approach has been limited by current spread resulting in distortion of the vestibular nerve activation pattern and consequent inability to accurately encode head movements throughout the full 3-dimensional (3D) range normally transduced by the labyrinths. We report that the electrically evoked 3D angular vestibulo-ocular reflex exhibits vector superposition and linearity to a sufficient degree that a multichannel vestibular prosthesis incorporating a precompensatory 3D coordinate transformation to correct misalignment can accurately emulate semicircular canals for head rotations throughout the range of 3D axes normally transduced by a healthy labyrinth.