Mechanism(s) of in utero meconium passage.
Mechanism(s) of in utero meconium passage.
复制标题
子宫内胎便通过的机制。
DOI：
10.1038/jp.2008.144
复制
发表时间：
2008
期刊：
影响因子：
--
通讯作者：
Ross,MG
中科院分区：
文献类型：
--
作者：
Lakshmanan,J;Ross,MG
目的：利用绵羊和大鼠模型，证实应激刺激激活胎儿糖皮质激素（GC）系统、促肾上腺皮质激素释放因子（CRF）系统和胆碱能神经递质系统（ChNS），导致结肠推进运动和胎粪通过。应用免疫组织化学方法对羊胎儿远端结肠GC受体、CRF受体及ChNS关键分子进行了定位研究。检测胎鼠胎盘和肠道内分泌细胞CRF的表达，并观察急性缺氧对胎鼠宫内胎粪排出的影响。IHS证实了羊胎结肠中GC-Rs、CRF-Rs和胆碱能标记物的定位和妊娠依赖性变化。大鼠胎盘和肠内分泌细胞表达CRF，胃肠道表达CRF-Rs。缺氧是足月胎鼠胎粪通过的强有力诱导剂。应激是宫内胎粪通过的危险因素，实验室动物模型可用于开发药物治疗以预防应激诱导的宫内胎粪通过。
To use sheep and rat models and demonstrate that stressors activate fetal glucocorticoid (GC) system, corticotrophin-releasing factor (CRF) system and cholinergic neurotransmitter system (ChNS) leading to propulsive colonic motility and in utero meconium passage. Immunohistochemical studies (IHS) were performed to localize GC-Receptors, CRF-receptors and key molecules of ChNS in sheep fetal distal colon. CRF expression in placenta and enteric endocrine cells in fetal rat system were examined and the effects of acute hypoxia on in utero meconium passage was tested. IHS confirmed localization and gestation dependent changes in GC-Rs, CRF-Rs and cholinergic markers in sheep fetal colon. Rat placenta and enteric endocrine cells express CRF and gastrointestinal tract express CRF-Rs. Hypoxia is a potent inducer of meconium passage in term fetal rats. Stress is a risk factor for in utero meconium passage and laboratory animal models can be used to develop pharmacotherapy to prevent stress-induced in utero meconium passage.