Toxicity, efficacy, and clearance of intravitreally injected of cefazolin.
Toxicity, efficacy, and clearance of intravitreally injected of cefazolin.
复制标题
玻璃体内注射头孢唑啉的毒性、功效和清除率。
DOI：
10.1001/archopht.1982.01030030652026
复制
发表时间：
1982
影响因子：
--
通讯作者：
R. Forster
中科院分区：
文献类型：
--
作者：
J. P. Fisher;S. Civiletto;R. Forster
在兔模型中评价玻璃体内注射头孢唑林钠的潜在毒性、有效性和治疗细菌性眼内炎的清除率。毒性评价包括间接检眼镜检查、暗视视网膜电图和组织病理学标本的光学显微镜检查。根据这些标准，观察2周后，给予剂量高达2.25 mg（含）头孢唑林钠的家兔未显示毒性反应证据。当在接种后24小时内注射时，2.25 mg头孢唑林钠可使感染金黄色葡萄球菌的6只兔眼中的5只绝育。玻璃体内注射2.25 mg头孢唑林钠后，超过金黄色葡萄球菌最低抑菌浓度的玻璃体浓度维持5天。2.25 mg剂量的头孢唑林钠在体内注射到有色家兔的玻璃体腔内时，似乎是无毒的，有效的，并且在长时间内对敏感生物体具有生物活性。
The intravitreal injection of cefazolin sodium was evaluated with respect to its potential toxicity, efficacy, and clearance in the treatment of bacterial endophthalmitis in the rabbit model. Toxicity evaluation included indirect ophthalmoscopy, scotopic electroretinogram, and light microscopy of histopathologic specimens. Rabbits given doses up to and including 2.25 mg of cefazolin sodium showed no evidence of toxic reaction by these criteria after two weeks of observation. When injected within 24 hours of inoculation, 2.25 mg of cefazolin sodium sterilized five of six rabbit eyes infected with Staphylococcus aureus. Following intravitreal injection of 2.25 mg of cefazolin sodium, vitreous concentrations in excess of the minimum inhibitory concentration for S aureus were maintained for five days. A 2.25-mg dose of cefazolin sodium appears to be nontoxic, effective, and biologically active against susceptible organisms during a prolonged period, when injected into the vitreous cavity of the pigmented rabbit in vivo.