Molecular characteristics and metastasis predictor genes of triple-negative breast cancer: a clinical study of triple-negative breast carcinomas.
Molecular characteristics and metastasis predictor genes of triple-negative breast cancer: a clinical study of triple-negative breast carcinomas.
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DOI：
10.1371/journal.pone.0045831
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Chuang EY
中科院分区：
文献类型：
--
作者：
Kuo WH;Chang YY;Lai LC;Tsai MH;Hsiao CK;Chang KJ;Chuang EY
三阴性乳腺癌是具有侵袭性肿瘤行为和独特疾病病因的乳腺癌亚型。由于缺乏有效的靶向药物，三阴性乳腺癌的治疗选择很少，复发率很高。虽然已经提出了各种多基因预后标记物用于预测乳腺癌的结果，但其中大多数被证明仅对雌激素受体阳性的乳腺癌有临床意义。目前尚不可能可靠地鉴定出预后良好的三阴性患者。本研究收集了1995年至2008年台湾大学附属医院157例浸润性乳腺癌的临床病理资料和微阵列数据。通过寡核苷酸微阵列生成51个三阴性和106个管腔型乳腺癌的基因表达数据。分层聚类分析显示，大多数（94%）三阴性乳腺癌紧密聚集在一起，携带强基底样特征。使用受试者操作特征分析和留一交叉验证确定了一个45基因的预后标记，该标记对我们的三阴性患者的远处复发具有98%的预测准确性。在59名早期三阴性患者的独立微阵列数据集中对预后特征的外部验证也获得了统计学显著性（风险比2.29，95%置信区间（CI）1.04-5.06，考克斯P = 0.04），优于其他五种已发表的乳腺癌预后特征。 本研究中鉴定的45个基因标签揭示了免疫/炎症调节的TGF-β信号传导可能在三阴性乳腺癌的远处转移侵袭中起重要作用。本研究收集并分析了三阴性乳腺癌的基因表达数据和复发信息。发现一组新的45个基因签名在三阴性乳腺癌的疾病复发中具有统计学预测性。如果进一步验证，45个基因签名可能是早期三阴性患者远处复发风险评估的临床有用工具。
Triple-negative breast cancer is a subtype of breast cancer with aggressive tumor behavior and distinct disease etiology. Due to the lack of an effective targeted medicine, treatment options for triple-negative breast cancer are few and recurrence rates are high. Although various multi-gene prognostic markers have been proposed for the prediction of breast cancer outcome, most of them were proven clinically useful only for estrogen receptor-positive breast cancers. Reliable identification of triple-negative patients with a favorable prognosis is not yet possible. Clinicopathological information and microarray data from 157 invasive breast carcinomas were collected at National Taiwan University Hospital from 1995 to 2008. Gene expression data of 51 triple-negative and 106 luminal breast cancers were generated by oligonucleotide microarrays. Hierarchical clustering analysis revealed that the majority (94%) of triple-negative breast cancers were tightly clustered together carrying strong basal-like characteristics. A 45-gene prognostic signature giving 98% predictive accuracy in distant recurrence of our triple-negative patients was determined using the receiver operating characteristic analysis and leave-one-out cross validation. External validation of the prognostic signature in an independent microarray dataset of 59 early-stage triple-negative patients also obtained statistical significance (hazard ratio 2.29, 95% confidence interval (CI) 1.04–5.06, Cox P = 0.04), outperforming five other published breast cancer prognostic signatures. The 45-gene signature identified in this study revealed that TGF-β signaling of immune/inflammatory regulation may play an important role in distant metastatic invasion of triple-negative breast cancer. Gene expression data and recurrence information of triple-negative breast cancer were collected and analyzed in this study. A novel set of 45-gene signature was found to be statistically predictive in disease recurrence of triple-negative breast cancer. The 45-gene signature, if further validated, may be a clinically useful tool in risk assessment of distant recurrence for early-stage triple-negative patients.
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影响因子：
82.9
作者：
Liu, Yawei;Teige, Ingrid;Issazadeh-Navikas, Shohreh
通讯作者：
Issazadeh-Navikas, Shohreh
DOI：
10.1073/pnas.0932692100
发表时间：
2003-07-08
影响因子：
11.1
作者：
Sorlie, T;Tibshirani, R;Botstein, D
通讯作者：
Botstein, D
影响因子：
11.5
作者：
Rakha, Emad A.;Elsheikh, Somaia E.;Ellis, Ian O.
通讯作者：
Ellis, Ian O.
影响因子：
3.8
作者：
Lund, Mary Jo;Trivers, Katrina F.;Eley, J. William
通讯作者：
Eley, J. William
影响因子：
4.4
作者：
Hu, Zhiyuan;Fan, Cheng;Perou, Charles M.
通讯作者：
Perou, Charles M.