Urine cadmium levels and albuminuria in a general population from Spain: A gene-environment interaction analysis
Urine cadmium levels and albuminuria in a general population from Spain: A gene-environment interaction analysis
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DOI：
10.1016/j.envint.2017.05.008
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发表时间：
2017-09-01
影响因子：
11.8
通讯作者：
Tellez-Plaza, Maria
中科院分区：
文献类型：
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作者：
Grau-Perez, Maria;Pichler, Gernot;Tellez-Plaza, Maria
背景：镉与参与氧化应激、镉代谢和蛋白尿转运途径的基因的相互作用可以在低暴露水平下为镉与蛋白尿之间的关系提供生物学上的见解。目的：我们检验了候选基因中特定的基因类型可能增加镉暴露易感性的假设。方法：通过电感耦合等离子体质谱(ICPMS)对参与Hortega研究的1397名18-85岁的男性和女性进行镉暴露评估，该研究是西班牙普通人群中的代表性样本。尿白蛋白测定采用全自动散射比浊法。异常蛋白尿定义为尿白蛋白大于或等于30 mg/g。结果：异常蛋白尿的加权患病率为6.3%。尿镉中位数为0.39(IQR，0.23~0.65)微克/克肌酐。多变量调整后的蛋白尿与最高和最低三分位数尿镉的几何平均数之比分别为1.62(95%CI，1.43~1.84)和2.94(95%CI，2.58~3.35)。蛋白尿异常的相对优势比分别为1.58(0.83，3.02)和4.54(2.58，8.00)。在所有被评估的参与者亚组中，包括没有高血压、糖尿病或慢性肾脏疾病的参与者，观察了尿镉和蛋白尿之间的联系。我们观察到经Bonferroni校正的尿镉水平与SLC30A7和RAC1基因多态之间的显著交互作用。结论：在西班牙一个具有代表性的普通人群样本中，尿镉浓度的增加与蛋白尿的增加是横截面相关的。氧化应激和镉代谢和转运基因的遗传变异可能赋予潜在的镉效应不同的易感性。
Background: The interaction of cadmium with genes involved in oxidative stress, cadmium metabolism and transport pathways on albuminuria can provide biological insight on the relationship between cadmium and albuminuria at low exposure levels.Objectives: We tested the hypothesis that specific genotypes in candidate genes may confer increased susceptibility to cadmium exposure.Methods: Cadmium exposure was estimated by inductively coupled plasma mass spectrometry (ICPMS) in urine from 1397 men and women aged 18-85 years participating in the Hortega Study, a representative sample of a general population from Spain. Urine albumin was measured by automated nephelometric immunochemistry. Abnormal albuminuria was defined as urine albumin greater than or equal to 30 mg/g.Results: The weighted prevalence of abnormal albuminuria was 6.3%. The median level of urine cadmium was 0.39 (IQR, 0.23-0.65) mu g/g creatinine. Multivariable-adjusted geometric mean ratios of albuminuria comparing the two highest to the lowest tertile of urine cadmium were 1.62 (95% CI, 1.43-1.84) and 2.94 (95% CI, 2.58-3.35), respectively. The corresponding odds ratios of abnormal albuminuria were 1.58 (0.83, 3.02) and 4.54 (2.58, 8.00). The association between urine cadmium and albuminuria was observed across all participant subgroups evaluated including participants without hypertension, diabetes or chronic kidney disease. We observed Bonferroni-corrected statistically significant interactions between urine cadmium levels and polymorphisms in gene SLC30A7 and RAC1.Conclusions: Increasing urine cadmium concentrations were cross-sectionally associated with increased albuminuria in a representative sample of a general population from Spain. Genetic variation in oxidative stress and cadmium metabolism and transport genes may confer differential susceptibility to potential cadmium effects.