Designing new MRI contrast agents: a coordination chemistry challenge
Designing new MRI contrast agents: a coordination chemistry challenge
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DOI：
10.1016/s0010-8545(99)00028-4
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发表时间：
1999-05-01
影响因子：
20.6
通讯作者：
Desreux, JF
中科院分区：
文献类型：
--
作者：
Comblin, V;Gilsoul, D;Desreux, JF
钆（III）多乙酸大环配合物具有直接接枝到1，4，7，10-四氮杂环十二烷上的环烷基基团，具有有趣的性质，例如更高的刚性，更好的动力学惰性和更快的水交换时间。顺磁性Yb（III）配合物的溶液结构从NMR光谱推断和Gd（III）螯合物对水的T-1弛豫时间的影响解释通过测量独立的参数，如水交换时间和扩散系数。用配位单元如1，10-菲咯啉取代四氮杂环导致双配位配体自发地形成具有良好定义的化学计量的异多金属Gd（III）-Fe（II）络合物，其对弛豫率具有掩蔽效应。(C)1999年Elsevier Science S.A. All rights reserved.
Gadolinium(III) polyacetic macrocyclic complexes featuring cycloalkyl groups directly grafted onto 1,4,7,10-tetra-azacyclododecane feature interesting properties such as higher rigidity, better kinetic inertness and faster water exchange times. The solution structures of the paramagnetic Yb(III) complexes are deduced from the NMR spectra and the effect of the Gd(III) chelates on the T-1 relaxation times of water is interpreted by measuring independently parameters such as the water exchange times and the diffusion coefficients. Substituting the tetra-aza ring with a coordinating unit such as 1,10-phenanthroline leads to ditopic ligands that spontaneously form heteropolymetallic Gd(III)-Fe(II) complexes of well-defined stoichiometry with a masked effect on relaxivity. (C) 1999 Elsevier Science S.A. All rights reserved.