Xenobiotic bioconversion in human epidermis models.
Xenobiotic bioconversion in human epidermis models.
复制标题
人类表皮模型中的异生素生物转化。
DOI：
10.1023/a:1025024309223
复制
发表时间：
2003
影响因子：
3.7
通讯作者：
Stinchcomb,AudraL
中科院分区：
文献类型：
--
作者：
Stinchcomb,AudraL
目前迫切需要替代的实验方法来测量经皮异种生物的生物转化。动物试验和人体皮肤切除研究一直是确认药物和其他化学新陈代谢导致的皮肤治疗和毒性影响的历史标准。近年来，人类皮肤表皮生物等效物越来越多地用于这些类型的药理学/毒理学研究。这些表皮模型已被用于细胞培养、组织片、高度分化的表皮和表皮/真皮系统。这篇综述重点介绍了这些皮肤生物等效性模型在各种类型的代谢和毒理学研究中的效用的现有发表数据，这些研究应该引起皮肤药物科学家的兴趣。
There is a great need for alternative experimental methods for measuring percutaneous xenobiotic biotransformation. Animal testing and excised human skin studies have been the historical standards for confirmation of therapeutic and toxic effects that occur in the skin as a result of drug and other chemical metabolism. Human skin epidermal bioequivalents have become progressively more used for these types of pharmacological/toxicological studies in recent years. These epidermal models have been used in the form of cell culture, tissue sheets, and highly differentiated epidermal and epidermal/dermal systems. This review highlights the existing published data on the utility of these skin bioequivalent models for various types of metabolism and toxicology studies that should be of interest to the dermatopharmaceutical scientist.