Systemic chemotherapy and sequential locoregional radiotherapy in initially metastatic nasopharyngeal carcinoma: Retrospective analysis with 821 cases
Systemic chemotherapy and sequential locoregional radiotherapy in initially metastatic nasopharyngeal carcinoma: Retrospective analysis with 821 cases
复制标题
全身化疗联合局部序贯放疗治疗原发转移性鼻咽癌821例回顾性分析
DOI：
10.1002/hed.26130
复制
发表时间：
2020-08-01
影响因子：
2.9
通讯作者：
Cai, Qingqing
中科院分区：
文献类型：
--
作者：
Huang, Tianying;Su, Ning;Cai, Qingqing
背景：我们设计了这项回顾性研究，以探讨鼻咽癌初发转移患者的最佳治疗方式。方法2008年至2017年共纳入821例患者。分析治疗方式和预后因素。结果与单纯化疗和放疗相比，全身化疗-序贯局部区域放疗可显著提高鼻咽癌患者的3年总生存率（40.3%，11.7%和22.9%，P <0.001）。紫杉醇联合铂类和氟尿嘧啶（TPF）方案作为一线化疗的总有效率高于紫杉醇联合铂类（TP）方案（78.2%vs70.0%，P = .038）。TPF组的3年总生存率（OS）高于双联方案（35.7%vs25.3%，P <0.001）。结论全身化疗-序贯局部放疗可延长部分初发转移鼻咽癌患者的OS和无进展生存期。
Background We designed this retrospective study to explore the best treatment modality for patients with initially metastatic nasopharyngeal carcinoma (NPC). Methods From 2008 to 2017, 821 patients were enrolled. Treatment modalities and prognostic factors were analyzed. Results Compared with chemotherapy alone and radiotherapy-based treatment, systemic chemotherapy-sequential locoregional radiotherapy to the nasopharyngeal primary tumor site were associated with a significantly increased 3-year overall survival (OS) rate (40.3%, 11.7%, and 22.9%,P < .001). The overall response rate of the paclitaxel combined with platinum and fluorouracil (TPF) regimen as first-line chemotherapy was higher than that of the paclitaxel plus platinum (TP) regimen (78.2% vs 70.0%,P= .038). A better OS was achieved in the TPF group compared to doublet drug regimens (3-year OS, 35.7% vs 25.3%,P < .001). Conclusions Systemic chemotherapy-sequential locoregional radiotherapy may prolong OS and progression-free survival for selected patients with initially metastatic NPC.