Submucosal injection of normal saline may prevent tissue damage from argon plasma coagulation: An experimental study using resected porcine esophagus, stomach, and colon
Submucosal injection of normal saline may prevent tissue damage from argon plasma coagulation: An experimental study using resected porcine esophagus, stomach, and colon
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DOI：
10.1097/01.sle.0000213739.85277.3d
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发表时间：
2006-10-01
影响因子：
1
通讯作者：
Omata, Masao
中科院分区：
文献类型：
--
作者：
Fujishiro, Mitsuhiro;Yahagi, Naohisa;Omata, Masao
氩等离子体凝固（APC）被认为是一种安全的热凝固技术，但一些报告显示APC期间和之后穿孔和畸形。在这项研究中，我们调查了事先粘膜下注射APC的有用性。对新鲜切除的猪食管、胃和结肠进行粘膜上APC，粘膜下注射生理盐水（注射组）和不注射生理盐水（对照组）。在两组中，组织损伤的深度随脉冲持续时间线性增加，直至较浅的粘膜下层。此后，在任何条件下，注射组的组织损伤仍然局限于较浅的粘膜下层，而对照组的组织损伤继续扩展。注射组的组织损伤程度明显浅于对照组（P < 0.05），并可达各器官的粘膜下层。在应用APC之前粘膜下注射生理盐水可以限制组织损伤并防止穿孔和畸形。
Argon plasma coagulation (APC) is considered to be a safe thermocoagulation technique, but some reports show perforation and deformity during and after APC. In this study, we investigated the usefulness of prior submucosal injection for APC. APC over the mucosa was performed on fresh resected porcine esophagus, stomach, and colon with prior submucosal injection of normal saline (injection group) and without it (control group). The depth of tissue damage increased linearly with pulse duration up to the shallower submucosal layer in both groups. After that, tissue damage in the injection group remained confined to the shallower submucosal layer under any condition, whereas that in the control group continued to extend. The tissue damages of the injection groups were significantly (P < 0.05) shallower than those of the control groups that reached the deeper submucosal layer in all the organs. Submucosal injection of normal saline before the application of APC may limit tissue damage and prevent perforation and deformity.