Calibration Phantom for Quantitative Tomography Analysis of Biodistribution of Magnetic Nanoparticles
Calibration Phantom for Quantitative Tomography Analysis of Biodistribution of Magnetic Nanoparticles
复制标题
用于磁性纳米粒子生物分布定量断层扫描分析的校准模型
DOI：
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发表时间：
2010
期刊：
影响因子：
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通讯作者：
S. Odenbach
中科院分区：
文献类型：
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作者：
H. Rahn;M. Kettering;H. Richter;I. Hilger;L. Trahms;S. Odenbach
Ferrofluids are being investigated for cancer treatments such as magnetic drug targeting (MDT) and magnetic heating treatments with the aim of treating the cancer locally, since magnetic nanoparticles with attached drugs are concentrated within the target region. Thus, the side effects are considerably reduced. One of the crucial factors for the success of these therapies is the magnetic nanoparticle distribution. Microcomputed X‐ray tomography (XμCT) has been introduced as adequate technique for non‐destructive three‐dimensional analysis of biological samples enriched with magnetic nanoparticles. The biological tissue specimens, in this case tumor bearing mice after intra‐tumoral magnetic nanoparticle injection, have been analyzed by means of XμCT. Complementary measurements have been performed by magnetorelaxometry (MRX). This technique enables a sensitive quantification of magnetic nanoparticles down to few nanograms. For multi‐phase samples, such as biological tissue enriched with magnetic nanoparticl...
