Elevated Extracellular Levels of Granzymes in Patients with Scrub Typhus
Elevated Extracellular Levels of Granzymes in Patients with Scrub Typhus
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DOI：
10.4269/ajtmh.20-1369
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发表时间：
2021-12-01
影响因子：
3.3
通讯作者：
Lee, Chang-Seop
中科院分区：
文献类型：
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作者：
Hwang, Joo-Hee;Hwang, Jeong-Hwan;Lee, Chang-Seop
森林斑疹伤寒是由恙虫病东方体引起的一种急性发热性疾病，通过恙螨螨类传播。延误治疗会导致各种并发症，严重时还会导致死亡。颗粒酶由细胞毒性T淋巴细胞或自然杀伤细胞分泌，在控制细胞内病原体方面发挥着重要作用。到目前为止，对斑疹伤寒患者颗粒酶的研究还很少。在本研究中，斑疹伤寒急性期颗粒酶A和B较健康对照组显著升高，治疗后显著下降。此外，在中度肝酶升高组中，颗粒酶A和B显著升高。总之，在斑疹伤寒的急性期，宿主似乎增加了细胞毒性T细胞的活性，以控制感染。
Scrub typhus is an acute febrile disease caused by Orientia tsutsugamushi, which is transmitted through chigger mites. Delayed treatment results in various complications and, in severe cases, death. Granzymes are secreted by cytotoxic T lymphocytes or natural killer cells and are known to play an important role in controlling intracellular pathogens. To date, few studies have been done on granzymes in patients with scrub typhus. In this study, granzymes A and B showed a significant increase during the acute stage of scrub typhus compared with healthy control subjects, and decreased sharply after treatment. In addition, granzymes A and B were significantly high in the moderately elevated liver enzyme group. In conclusion, it appears that the host during the acute phase of scrub typhus increases cytotoxic T-cell activity to control infection.