What qualities are most important to making a point of care test desirable for clinicians and others offering sexually transmitted infection testing?
What qualities are most important to making a point of care test desirable for clinicians and others offering sexually transmitted infection testing?
复制标题
DOI：
10.1371/journal.pone.0019263
复制
发表时间：
2011-04-29
期刊：
影响因子：
3.7
通讯作者：
Rompalo AM
中科院分区：
文献类型：
--
作者：
Hsieh YH;Gaydos CA;Hogan MT;Uy OM;Jackman J;Jett-Goheen M;Albertie A;Dangerfield DT 2nd;Neustadt CR;Wiener ZS;Rompalo AM
目的：探讨不同水平的即时检测（POCT）属性对性传播感染（STI）专业人员决定理想的即时检测（POCT）的可能影响。在对科技创新专家和专业人员进行大规模深入焦点讨论研究的基础上，设计了一项在线调查。调查的最后一部分“建立你自己的POCT”是采用离散选择实验方法设计的。来自两个地方的执业临床医生、性病相关国际会议的与会者和美国性病临床医生被邀请参与调查。采用条件逻辑回归模型进行数据分析。总共有256名受试者参加了在线调查，其中218人（85%）完成了调查。大多数参与者是性病临床医生，他们已经在实践中使用了一些poct。“所需的时间框架”被认为是目前难以使用STI poct的主要障碍。沙眼衣原体被选为一种新的POCT的首选生物，其次是一种可以诊断HIV早期血清转化的测试，以及一种梅毒POCT。无论选择何种生物类型，90-99%的灵敏度始终是最重要的考虑因素，其次是20美元的成本。然而，当检测平台优先用于早期HIV血清转化或梅毒时，敏感性仍然是最重要的，而特异性被评为第二重要。STI专业人员首选沙眼原体作为新的POCT的首选，其灵敏度超过90%，成本低，完成时间短。
To investigate the possible effects of different levels of attributes of a point-of-care test (POCT) on sexually transmitted infection (STI) professionals' decisions regarding an ideal POCT for STI(s). An online survey was designed based on a large-scale in-depth focus discussion study among STI experts and professionals. The last section of the survey “build your own POCT” was designed by employing the discrete choice experiment approach. Practicing clinicians from two venues, STI-related international conference attendees and U.S. STD clinic clinicians were invited to participate in the survey. Conditional logistical regression modeling was used for data analysis. Overall, 256 subjects took the online survey with 218 (85%) completing it. Most of the participants were STD clinic clinicians who already used some POCTs in their practice. “The time frame required” was identified as a major barrier that currently made it difficult to use STI POCTs. Chlamydia trachomatis was the organism chosen as the top priority for a new POCT, followed by a test that would diagnose early seroconversion for HIV, and a syphilis POCT. Without regard to organism type selected, sensitivity of 90–99% was always the most important attribute to be considered, followed by a cost of $20. However, when the test platform was prioritized for early HIV seroconversion or syphilis, sensitivity was still ranked as most important, but specificity was rated second most important. STI professionals preferred C. trachomatis as the top priority for a new POCT with sensitivity over 90%, low cost, and a very short completion time.
登录
查看更多内容
影响因子：
3.6
作者：
van Dommelen, Laura;van Tiel, Frank H.;Hoebe, Christian J. P. A.
通讯作者：
Hoebe, Christian J. P. A.
影响因子：
3
作者：
Chan, Yiu Man;Sahota, Daljit Singh;Lau, Tze Kin
通讯作者：
Lau, Tze Kin
影响因子：
--
作者：
Huppert J;Hesse E;Gaydos CA
通讯作者：
Gaydos CA
影响因子：
3.6
作者：
Peeling, R. W.;Holmes, K. K.;Ronald, A.
通讯作者：
Ronald, A.
影响因子：
3.7
作者：
Hsieh YH;Hogan MT;Barnes M;Jett-Goheen M;Huppert J;Rompalo AM;Gaydos CA
通讯作者：
Gaydos CA