Rho GTPase function in flies: insights from a developmental and organismal perspective
Rho GTPase function in flies: insights from a developmental and organismal perspective
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DOI：
10.1139/o04-118
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发表时间：
2004-12-01
影响因子：
2.9
通讯作者：
Parkhurst, SM
中科院分区：
文献类型：
--
作者：
Johndrow, JE;Magie, CR;Parkhurst, SM
形态发生是多细胞生物体发育的关键事件，依赖于协调的转录和信号转导事件。为了建立多细胞动物发育的基础，个体细胞和细胞群必须以复杂的运动和形状变化来响应外源信号。在将细胞外信号解释为细胞行为中起关键作用的一类蛋白质是小GTP酶的Rho家族。这些分子开关是越来越多的信号通路的重要组成部分，其中许多调节肌动蛋白细胞骨架重塑。我们对Rho生物学的大部分理解都来自于细胞培养中的工作。最近，果蝇（Drosophila melanogaster）已经成为研究这些蛋白质在发育和生物体背景下的一个极好的遗传系统。对果蝇的研究极大地增强了我们对Rho GTP酶通路及其在发育中作用的理解。
Morphogenesis is a key event in the development of a multicellular organism and is reliant on coordinated transcriptional and signal transduction events. To establish the segmented body plan that underlies much of metazoan development, individual cells and groups of cells must respond to exogenous signals with complex movements and shape changes. One class of proteins that plays a pivotal role in the interpretation of extracellular cues into cellular behavior is the Rho family of small GTPases. These molecular switches are essential components of a growing number of signaling pathways, many of which regulate actin cytoskeletal remodeling. Much of our understanding of Rho biology has come from work done in cell culture. More recently, the fruit fly Drosophila melanogaster has emerged as an excellent genetic system for the study of these proteins in a developmental and organismal context. Studies in flies have greatly enhanced our understanding of pathways involving Rho GTPases and their roles in development.