Convergent evolution of complex genomic rearrangements in two fungal meiotic drive elements.
Convergent evolution of complex genomic rearrangements in two fungal meiotic drive elements.
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DOI：
10.1038/s41467-018-06562-x
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发表时间：
2018-10-12
影响因子：
16.6
通讯作者：
Johannesson H
中科院分区：
文献类型：
--
作者：
Svedberg J;Hosseini S;Chen J;Vogan AA;Mozgova I;Hennig L;Manitchotpisit P;Abusharekh A;Hammond TM;Lascoux M;Johannesson H
减数分裂驱动在自然界中广泛存在。它所产生的冲突有望成为进化变革和创新的重要动力。在这项研究中，我们研究了丝状子囊菌中间脉孢菌中发现的两个大的多基因减数分裂驱动元件，Sk-2和Sk-3的基因组后果。使用长读测序，我们产生了第一个完整的和注释良好的基因组组件的大，高度分歧，非重组区域与减数分裂驱动元件。系统发育分析表明，尽管Sk-2和Sk-3位于同一染色体区域，但它们并不形成姐妹分支，这表明它们具有独立的起源或至少是长期的进化分离。我们的结论是，他们在一个收敛的方式积累了类似的模式的串联倒位和密集的重复序列簇，大概是在响应类似的需要，以建立基因之间的联系，导致驱动器和电阻。减数分裂驱动元件是自私的遗传元件，其介导从父母到后代的性传递的偏斜。在这里，作者测序和分析大型和复杂的基因组区域与真菌中间脉孢菌减数分裂驱动元件。
Meiotic drive is widespread in nature. The conflict it generates is expected to be an important motor for evolutionary change and innovation. In this study, we investigated the genomic consequences of two large multi-gene meiotic drive elements, Sk-2 and Sk-3, found in the filamentous ascomycete Neurospora intermedia. Using long-read sequencing, we generated the first complete and well-annotated genome assemblies of large, highly diverged, non-recombining regions associated with meiotic drive elements. Phylogenetic analysis shows that, even though Sk-2 and Sk-3 are located in the same chromosomal region, they do not form sister clades, suggesting independent origins or at least a long evolutionary separation. We conclude that they have in a convergent manner accumulated similar patterns of tandem inversions and dense repeat clusters, presumably in response to similar needs to create linkage between genes causing drive and resistance. Meiotic drive elements are selfish genetic elements that mediate a skew in their sexual transmission from parent to offspring. Here, the authors sequence and analyze large and complex genomic regions associated with meiotic drive elements in the fungus Neurospora intermedia.
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影响因子：
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作者：
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通讯作者：
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作者：
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通讯作者：
Giraud T