Ultrasound enhanced drug delivery to the brain and central nervous system.
Ultrasound enhanced drug delivery to the brain and central nervous system.
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DOI：
10.3109/02656736.2012.666709
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Hynynen K
中科院分区：
文献类型：
--
作者：
O'Reilly MA;Hynynen K
人们对使用超声来增强药物向大脑和中枢神经系统的递送越来越感兴趣。由于血脑屏障（BBB）的存在，脑和CNS疾病对药物治疗的反应一直很差。用于绕过BBB的技术通常是高度侵入性的或涉及破坏大部分BBB，使大脑暴露于病原体。超声波可以通过完整的颅骨非侵入性地传递到大脑。当与预先形成的微泡组合时，超声可以安全地诱导BBB的短暂的、局部的和可逆的破坏，从而允许递送治疗剂。迄今为止的研究表明，在原发性和转移性脑癌和阿尔茨海默病的啮齿动物模型中，对超声BBB破坏与治疗剂递送的组合有积极的反应。最近在非人类灵长类动物中的工作表明，该技术适用于人类。本文综述了通过破坏血脑屏障和通过超声增强已经受损的血脑屏障向大脑和中枢神经系统递送药物的现状。讨论了破坏的细胞和物理机制，以及治疗技术、安全性和监测。
There is an increasing interest in the use of ultrasound to enhance drug delivery to the brain and central nervous system. Disorders of the brain and CNS historically have had poor response to drug therapy due to the presence of the Blood-Brain barrier (BBB). Techniques for circumventing the BBB are typically highly invasive or involve disrupting large portions of the BBB, exposing the brain to pathogens. Ultrasound can be non-invasively delivered to the brain through the intact skull. When combined with preformed microbubbles, ultrasound can safely induce transient, localized and reversible disruption of the BBB, allowing therapeutics to be delivered. Investigations to date have shown positive response to ultrasound BBB disruption combined with therapeutic agent delivery in rodent models of primary and metastatic brain cancer and Alzheimer’s disease. Recent work in non-human primates has demonstrated that the technique is feasible for use in humans. This review examines the current status of drug delivery to the brain and CNS both by disruption of the BBB, and by ultrasound enhancement of drug delivery through the already compromised BBB. Cellular and physical mechanisms of disruption are discussed, as well as treatment technique, safety and monitoring.
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影响因子：
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作者：
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通讯作者：
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DOI：
10.1109/tbme.2009.2034533
发表时间：
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期刊：
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