The kinetics of red blood cell electrolyte alterations following digoxin administration. A report of two pediatric cases.
The kinetics of red blood cell electrolyte alterations following digoxin administration. A report of two pediatric cases.
复制标题
地高辛给药后红细胞电解质变化的动力学。
DOI：
10.1159/000457420
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发表时间：
1981
期刊：
影响因子：
--
通讯作者：
Mirkin,BL
中科院分区：
文献类型：
--
作者：
Loes,MW;Lock,JE;Singh,S;Mirkin,BL
Serial determinations of plasma and red blood cell (RBC) Na\ K+, and Mg++concentrations were obtained in 2 children following digoxin administration. Treatment with digoxin was associated with a 50-70% increase in the RBC Na+ concentration,whereas the RBC K+ concentration decreased by 7-10%. RBC electrolyte changes paralleled plasma digoxin levels in the child who was digitalized slowly, whereas the maximum shift in RBC electrolyte concentration occurred 48 h after peak plasma digoxin concentrations were observed in the child who had received a single dose of digoxin. These results suggest that Na+/K+-ATPase inhibition may continue after clearance of digoxin from the plasma. The use of plasma digoxin concentration to diagnose toxicity may be limited in the special case of children who have received a single large dose of digoxin.
