Animal Models of Lupus and Lupus Nephritis
Animal Models of Lupus and Lupus Nephritis
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DOI：
10.2174/1381612821666150316115727
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发表时间：
2015-01-01
影响因子：
3.1
通讯作者：
Mohan, Chandra
中科院分区：
文献类型：
--
作者：
Du, Yong;Sanam, Soomro;Mohan, Chandra
本文综述了研究狼疮和狼疮性肾炎的常用小鼠品系，包括自发发展狼疮的品系、同源品系、狼疮诱导模型，以及带有转基因或基因敲除的狼疮基因工程小鼠模型。该综述随后总结了导致这种自身免疫性疾病发病机制的主要细胞和分子途径，包括自身抗体。最后，它总结了通过使用狼疮小鼠模型获得的治疗见解。总而言之，我们对狼疮的了解大部分来自于研究该疾病的小鼠模型，而实验室小鼠仍然是研究人类系统性红斑狼疮的最佳工具之一。
This article reviews the commonly used murine strains for studying lupus and lupus nephritis, including strains that develop lupus spontaneously, congenic strains, induced models of lupus, as well as genetically engineered mouse models of lupus bearing transgenes or knockouts. The review then summarizes the main cellular and molecular pathways that lead to the pathogenesis of this autoimmune disease, including autoantibodies. Finally, it concludes with therapeutic insights gained from using mouse models of lupus. To sum, much of what we have learned about lupus has arisen from studying mouse models of the disease, and the laboratory mouse continues to be one of the best tools for studying human SLE.