Targeting Notch3 in Hepatocellular Carcinoma: Molecular Mechanisms and Therapeutic Perspectives.
Targeting Notch3 in Hepatocellular Carcinoma: Molecular Mechanisms and Therapeutic Perspectives.
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DOI：
10.3390/ijms18010056
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发表时间：
2016-12-28
影响因子：
5.6
通讯作者：
Gramantieri L
中科院分区：
文献类型：
--
作者：
Giovannini C;Bolondi L;Gramantieri L
Notch信号通路是一个非常保守的系统，通过细胞间通讯控制胚胎细胞的命运决定和成体干细胞的维持。越来越多的证据支持Notch信号在不同人类疾病中的相关性，并且它是癌症中最常见的激活信号通路之一。本文就Notch3信号通路在肝癌中的作用及其在肝癌治疗中的应用作一综述。在这方面，Notch和p53之间的串扰可能发挥重要作用。
The Notch signaling pathway is a very conserved system that controls embryonic cell fate decisions and the maintenance of adult stem cells through cell to cell communication. Accumulating evidence support the relevance of Notch signaling in different human diseases and it is one of the most commonly activated signaling pathways in cancer. This review focuses mainly on the role of Notch3 signaling in hepatocellular carcinoma and its potential therapeutic applications against this malignancy. In this regard, the crosstalk between Notch and p53 may play an important role.