MONICA: a compact, portable dual gamma camera system for mouse whole-body imaging
MONICA: a compact, portable dual gamma camera system for mouse whole-body imaging
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DOI：
10.1016/j.nucmedbio.2009.12.003
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发表时间：
2010-04-01
影响因子：
3.1
通讯作者：
Choyke, Peter L.
中科院分区：
文献类型：
--
作者：
Xi, Wenze;Seidel, Jurgen;Choyke, Peter L.
简介：我们描述了一种紧凑型便携式双伽马相机系统（称为“MONICA”，用于移动核成像相机），用于可视化和分析小鼠大小的动物中推定的诊断和治疗单光子发射放射性示踪剂的全身生物分布。方法：制造了两个相同的微型像素化 Na(TI) 伽马相机，并通过紧凑型便携式推车的桌面“向上查找”安装。将小鼠直接放置在桌面上进行成像。使用模型评估相机成像性能，并在小鼠肿瘤异种移植模型中进行的为期一周的 In-111 成像研究中评估场性能。结果：使用 140 keV +/- 10% 的光峰能量窗口进行 Tc-99m 性能测量，得出以下结果：空间分辨率（1 cm 处的 FWHM）为 2.2 mm；灵敏度，149 cps（每秒计数）/MBq（5.5 cps/mu Ci）；能量分辨率（FWHM，半高全宽）。 10.8%；计数率线性（计数率与活动度），视场 (FOV) 内 0-185 MBq (0-5 mCi) 时 r(2)=0.99；空间均匀性，
Introduction: We describe a compact, portable dual-gamma camera system (named "MONICA" for MObile Nuclear Imaging CAmeras) for visualizing and analyzing the whole-body biodistribution of putative diagnostic and therapeutic single photon emitting radiotracers in animals the size of mice.Methods: Two identical, miniature pixelated Na(TI) gamma cameras were fabricated and installed "looking up" through the tabletop of a compact portable cart. Mice are placed directly on the tabletop for imaging. Camera imaging performance was evaluated with phantoms and field performance was evaluated in a weeklong In-111 imaging study performed in a mouse tumor xenograft model.Results: Tc-99m performance measurements, using a photopeak energy window of 140 keV +/- 10%, yielded the following results: spatial resolution (FWHM at 1 cm), 2.2 mm; sensitivity, 149 cps (counts per seconds)/MBq (5.5 cps/mu Ci); energy resolution (FWHM, full width at half maximum). 10.8%; count rate linearity (count rate vs. activity), r(2)=0.99 for 0-185 MBq (0-5 mCi) in the field of view (FOV); spatial uniformity,